Frontiers of Engineering Reports on Leading-Edge Engineering from the 2004 NAE Symposium on Frontiers of Engineering (2005) / Chapter Skim
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Balancing Scales in Biological Models--Adam Paul Arkin
Balancing Scales in Biological Models--Adam Paul Arkin
Pages 87-88
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From page 87... ...
On short time scales, biologists study the kinetics of single enzymes and the temporal evolution of a product from a substrate. On longer time scales, they study the evolution of cellular behaviors that result from the integrated dynamics of the network of nonlinear, and possibly stochastic, chemical reactions that link genome to physiology and respond to environmental signals.
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From page 88... ...
; to demonstrate consistency, as when a number of assertions in the form of biochemical reactions in a cell are combined into an integrated model of a process, such as bacterial chemotaxis, to show that these reactions are sufficient to explain a cellular behavior, such as exact adaptation to a step of chemoattractant; and to explore teleology, that is, to demonstrate why something is the way it is. For example, models may be used to explain why an integral feedback is necessary for small, free-swimming cells, such as flagellated bacteria, to sense and follow a chemical gradient.
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