Cord Blood Establishing a National Hematopoietic Stem Cell Bank Program (2005) / Chapter Skim
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Pages 301-314
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From page 301... ...
, 25, 79, 9697, 102 Accreditation recommendations, 99102 Standards Committee, 97 accrediting organization, 102 American Red Cross (ARC) , 24, 87, 199 collection site, 100 Cord Blood Program, 80 cord blood banks, 100101 American Society for Histocompatibility transplant facility, 101 and Immunogenetics (ASHI)
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, 45, 209217 Clinical testing and quality control, 248 failures treatable by transplantation of 249 cord blood, 63 Clinical use of cord blood in treating Bone Marrow Donors Worldwide (BMDW) , inherited diseases, examples of 122123, 258 effective, 62 Bone marrow transplantation (BMT)
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From page 303... ...
, 100101, 297. patient survival time, 222231 See also Private cord blood banks; sensitivity analyses, 237238 Public cord blood banks; individual Cost estimates, 234235 cord blood banks by inventory level, 235 applying uniform quality standards to Cost model, 231232 all, 297 parameters, 233 cost recovery by, 125 Cost per life year gained, as a function of currently collecting units, 166 cord inventory, 236 defined, 7679 Costs, 196197, 231235 developing, 2324 associated with increasing the inventory, funding to promote inventory growth, 125126 17, 137, 198199 recovering, 125 options for, 78 of transplantation, 234 reputation of, 123 of typing, 254 responding, 160 Creutzfeldt-Jakob disease (CJF)
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From page 304... ...
See also Autoimmune disclosure of information regarding diseases; Central nervous system screening and other risks, 112114 disease; Genetic diseases treatable by informed consent of donors, 107112 transplantation of cord blood; maintenance of donor records and Immune deficiency diseases; patient privacy, 114117 Infectious disease; Inherited diseases European donors, 22 Distribution systems, for hematopoietic standards for, 98 progenitor cells, 10, 130 European Federation for Immunogenetics DNA-based testing, 114, 243, 250251, (EFI) , 248 254256, 261 European Group for Blood and Marrow Transplantation (EBMT)
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From page 305... ...
, 5, 78, 11, inventory growth, 17, 137, 198199 1314, 26, 80, 102, 132 Hematological chimerism, 68 Hematological malignancies, 60 G Hematopoietic progenitor cell (HPC) , 17, 13, 5657, 59, 6369, 75, 97, 127, Gastrointestinal disorders, umbilical cord 298 blood in, 68 distribution systems for, 10, 130 Genetic diseases treatable by transplantation donating, 23 of cord blood, 63, 69 ex vivo expansion of cord blood derived bone marrow failures, 63 from, 5859 immune deficiency diseases, 21, 63 homing receptors, 61 metabolic storage disorders, 21, 63 multipotent, 33 Genetic screening, 184 sources of, 5 Good tissue practice (GTP)
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From page 306... ...
system, mismatches, 260 244248 Hispanic donors, 50, 87, 95 allele and haplotype frequencies, 247248 Histocompatibility, 121 antigen presentation function, 244245 HLA Nomenclature Committee, 249 MHC-encoded HLA proteins, 244 Homing receptors, upregulation of, 61 Human transplantation data, 211212 HPCs, developing an outcomes database for Hurler syndrome, umbilical cord blood in, all sources of, 1617, 136 62 Human cellular and tissue-based products (HCT/Ps) , 9293 Human histocompatibility genes, 37, 246 I Human immunodeficiency virus (HIV)
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From page 307... ...
level, 37, 264 Inventory of a National Cord Blood Stem generic or serologic or antigen, 253 Cell Bank Program, 19, 120128 mismatches, 260 costs associated with increasing the at serological broad, 252 inventory, 125126 at serological split, 253 existing cord blood inventory, 122124 Lymphohematopoiesis, 22 Lymphomas, 21
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From page 308... ...
See National Cord Blood model, 277 Policy Board McCarthy Cord Blood Bank, 87 National Bone Marrow Donor Registry Medical information, promoting the security (NBMDR) , 24 of, 9, 116117 National Cord Blood Bank Program.
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From page 309... ...
See also Potential nonhematopoietic differentiation P from bone marrow cells; Potential nonhematopoietic uses for stem cells Panel on Cost-Effectiveness in Medicine and in cord blood Health, 234 determining usefulness of cord blood in, Parameter values for costs, 232234 216 administrative costs, 234 Nonhematopoietic tissues collection and storage costs, 233234 in clinical specimens, circulating cells cost of transplantation, 234 contribution to, 212 discard rate, 233 differentiation from HSCs, 210211 discount rate, 234 mechanism of HSC-derived initial endowment, 234 incorporation in, 213214
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From page 310... ...
See also National Cord Blood collection of cord blood units, 8283 Policy Board; National inventory screening maternal donors and cord policy blood, 8182 regarding who must provide consent, storage, 8486 cord blood centers needing, 9, 109 transport of cord blood and cell 110 viability, 8384 Polymorphic sequences, 246, 250 Proposed structure of a national program, Potential nonhematopoietic differentiation 15 from bone marrow cells, 209214, Public cord blood banks, 76, 78, 158159, 263264 161, 298 after bone marrow transplantation, 209 Public Cord Blood Tissue Bank, 9495 210 Pulse duplicator bioreactors, 65 human transplantation data, 211212 lack of engraftment reported, 213 mechanism of HSC-derived Q incorporation in nonhematopoietic tissue, 213214 Quality assurance systems, 100 nonhematopoietic differentiation from establishing uniform, 8, 86 Quality of life of patients, 120 HSCs, 210211 prevalence of "transdifferentiation," 213 Potential nonhematopoietic uses for stem R cells in cord blood, 208217 abstract, 208209 Racial and ethnic compositions, 124 determining usefulness of CB in non- of the units in cord blood banks, 8687, hematopoietic repair, 216 167 differences between stem cells in cord Raw data analysis, 146 blood and bone marrow, 216217 Receptor contact residues, 246 evidence, 214215 Recombinant human stem cell factor implications for cell therapy using CB or (rHuSCF) , 61 BM transplantation, 215216 Recommendations, 19 introduction, 209 applying uniform quality standards to all major discrepancies clouding the field, cord blood banks, 8, 103 214215 continuing to conduct outcomes research, 11, 127
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From page 311... ...
INDEX 311 cord blood centers needing policies Registries, 298 regarding who must provide consent, cord blood banks as repositories, 266 9, 109110 international, 258 cord blood donors understanding the optimizing size to find a match, 265266 limitation of their rights, 9, 118 Registry search algorithms, selection of developing a mechanism to make potential HLA matches by, 263264 nonclinical units available for Regression analysis, 83 research use, 1819, 69 Relapse risk, 44 developing an outcomes database for all and graft-versus-leukemia effect, 47 sources of HPCs, 1617, 136 Related donors, 257 establishing a National Cord Blood Relationships that the IOM committee Coordinating Center, 1416, 133 envisions under the governance 134 structure described in its establishing a National Cord Blood recommendations, 135 Policy Board, 14, 132133 Replicative capacities of cells, 35 establishing a national inventory policy, Research, 19, 5674, 266 10, 126127 developing a mechanism to make establishing criteria for data sharing, 18, nonclinical units available for, 18 138 19, 69 establishing FDA licensure of cord blood developing research priorities, 69 units, 8, 94 effective clinical use of cord blood in establishing uniform quality assurance treating inherited diseases, 6263 systems, 8, 86 genetic diseases treatable by establishing uniform standards for cord transplantation of cord blood, 63 blood collection, 8, 83 improving current transplant technology, expanding the current inventory, 11, 5661 127 registries/cord blood banks as funding banks to promote inventory repositories, 266 growth, 17, 137 umbilical cord blood in regenerative identifying a Cord Blood Accrediting medicine, 6469 Organization, 8, 80 Research Involving Human Biological obtaining informed consent prior to Materials: Ethical Issues and Policy labor and delivery, 9, 111 Guidance, 115 promoting the security of medical Results. See also Survey results information, 9, 116117 confirming, 282 providing donors with clear information Rights, of cord blood donors, limiting, 9, about their options, 9, 111 118 providing financial support for infrastructure development, 1718, 138 S Recommended direction for accreditation, 99102 San Diego donors, 87 Scientific Advisory Committee for Organ an accrediting organization, 102 collection site, 100 Transplantation, 133 cord blood banks, 100101 Screening completed prior to storage, 184 191 transplant facility, 101 Recommended structure of a national genetic screening, 184 program, 129139 infectious disease testing, 185187 other exclusions, 188191 national oversight, 132133 structure and governance, 133139 Screening maternal donors, and cord blood, Regenerative potential, 68 8182
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, international registries and cord blood 191 banks, 258 Summaries related donors, 257 of current research, 64 SouthEastern Organ Procurement of HLA matches, 264265 Foundation (SEOPF) , 249 of recommendations for establishing a Spinal cord injury, umbilical cord blood in, National Cord Blood Stem Cell Bank 6667 program, 19 St.
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From page 313... ...
level, 253 Texas Cord Blood Bank, 96 Ulcerative colitis, 68 Texas donors, 95 Umbilical cord blood (UCB) , 299 Thawing, 101 biological characteristics of, 3338 Timing of consent, 110111 as effector cells, 63 Tissue typing, 248256 Umbilical Cord Blood Banking Act, 96 clinical testing and quality control, 248 Umbilical cord blood (UCB)
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From page 314... ...
0201, examples of, 256 Umbilical cord blood (UCB) in regenerative medicine, 6469 brain injury, 6768 W cardiac repair, 6566 West Nile virus (WNV)
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