Designing Nanostructures at the Interface between Biomedical and Physical Systems Conference Focus Group Summaries (2005) / Chapter Skim
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Build a System That will Detect Disease In Vivo and Report Back Results
Build a System That will Detect Disease In Vivo and Report Back Results
Pages 23-30
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From page 23... ...
Examples include neuron dysfunction in Alzheimers, ' unregulated cell proliferation in cancer, or atherosclerosis in blood vessels. The body has natural surveillance mechanisms, such as immune cells, which continuously circulate through the blood, lymph, and tissues and detect foreign invaders; however, technological analogs that could survey the body `from the inside' to detect disease early are not available.
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From page 24... ...
Keep in mind burgeoning efforts to identify molecular markers using genomic/ proteomic technologies for many disease processes. · Consider how detection of diseased tissue would be reported to the physician.
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From page 25... ...
, Department of Chemistry and Biochemistry, The University of Texas at Austin · Stephen Boppart, Assistant Professor, Department of Electrical and Computer Engineering, University of Illinois, Urbana · William Bunney, Jr., Distinguished Professor, Della Martin Chair of Psychiatry, Department of Psychiatry and Human Behavior, University of California, Irvine · Denis Buxton, Associate Program Director, National Heart, Lung, and Blood Institute, NHLBI, National Institutes of Health · Mary Jane Cunningham, Associate Director, Department of Life Sciences & Health, Houston Advanced Research Center · Bob Hwang, Department of Chemical Engineering, Brookhaven National Laboratory · Cato Laurencin, University Professor, Department of Orthopedic Surgery, University of Virginia Health System · David Lynn, Assistant Professor, Department of Chemical and Biological Engineering, The University of Wisconsin, Madison · Andrew Lyon, Associate Professor, School of Chemistry and Biochemistry, Georgia Institute of Technology · James Noyes, Professor, Department of Mathematics and Computer Science, Wittenberg University · Babak Parviz, Assistant Professor, Department of Electrical Engineering, University of Washington · Jeremy Paul, Director, Frontiers of Science, New York Academy of Sciences
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From page 26... ...
Sohn, Assistant Professor, Department of Mechanical Engineering, University of California, Berkeley · Andreas von Bubnoff, Graduate Student, Science Communication Program, University of California, Santa Cruz · Patrick Winter, Research Instructor, Cardiovascular Division, Washington University Summary Remember the 1966 Science Fiction movie Fantastic Voyage where the protagonists travel inside the body to remove a blood clot? Thirty-nine years later, Focus Group 3 did not quite suggest sending people inside the body to detect disease.
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From page 27... ...
Alternatively, one could use a RAMAN active substance for the inner PEG layer. Different substances could emit different wavelengths after excitation with laser light, and this could serve as a particle ID.
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From page 28... ...
For example, tumor blood vessels express molecular markers that can even be specific for a given type of cancer. Stage 2 would be to detect targets outside the peripheral blood system, in the intercellular space.
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From page 29... ...
Group members agreed that the societal impact of the nanotrailmix technology would be positive in that it would be easily deployable to developing countries, and it would enable the collection of new research data for epidemiological studies. However, there was concern about privacy issues, with the collection of so much data, and about possible false negative or positive results.
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From page 30... ...
"It was intriguing and enthralling to brainstorm with people of such diverse backgrounds," one group member said. "The networking through brainstorming was a very effective mechanism."
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