Biographical Memoirs Volume 87 (2005) / Chapter Skim
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Martin Glover Larrabee
Martin Glover Larrabee
Pages 234-249
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From page 234... ...
Maryland Timonium, Inc., Photography, Lightner by Photo
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From page 235... ...
Whatever he undertook was done thoroughly and properly. He did not believe in shortcuts; for instance, he disapproved of double publication of similar findings both in book chapters and in research papers, so that some of his students' thesis work appeared in print only as part of chapters in symposium volumes.
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From page 236... ...
He graduated as a physics major from Harvard College in 1932 after also considering engineering. During college he had spent a summer doing optics at Dartmouth and, more significantly, spent the summer of 1931 working with Keffer Hartline at the Marine Biological Laboratory in Woods Hole, Massachusetts.
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From page 237... ...
(Their biophysical studies coincided with Feldberg's pharmacological studies of synaptic transmission in ganglia.) The advantages of this preparation include a relatively simple anatomy and physiology, easy accessibility, and a size, at least for rat and chick ganglia, small enough to be supplied adequately with oxygen and nutrients by simple diffusion.
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From page 238... ...
. After the war Mart soon returned to the study of sympathetic ganglia; he worked with the first of his many international postdoctoral fellows, Jean Posternak, from Switzerland, whom he often visited in later years.
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From page 239... ...
Meanwhile, his research had returned to general anesthesia, and in particular to the issue of whether anesthetics' actions on synaptic transmission were direct or indirect through block of metabolism. Working with Juan Garcia Ramos from Mexico and Edith Bulbring from England on rabbit ganglia, he showed that anesthetics blocked transmission at concentrations that did not affect oxygen consumption, whereas metabolic poisons blocked both in parallel (1952)
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From page 240... ...
Rat ganglia also supported a brief diversion into virology and observation of a puzzling pattern of ganglionic discharge brought on by infection with pseudorabies virus (1955)
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From page 241... ...
Mart formally retired from Hopkins in 1975 upon reaching the age of 65 but was able to gain emeritus status, hold on to some research space, and maintain his research grant from the National Institutes of Health. This grant, titled "Metabolism and Function in Sympathetic Ganglia" and first
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From page 242... ...
Working mostly on his own, Mart stayed in the lab for more than 20 years beyond his formal retirement and published 15 additional research papers. He maintained his interest in intermediary metabolism but turned from studying effects of activity in rat ganglia to studying development in chick ganglia, noting transitions in glucose utilization from anaerobic glycolysis (poor blood supply)
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From page 243... ...
He sputtered and fumed magnificently until it was pointed out to him that the glass tubing with the goldfish had been added in parallel to the actual distilled water line. He later accepted this student prank with typical good humor, although it did take him a while to cool down at the time.
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From page 244... ...
Beginning when I was a student, Mart undertook to emulate his father by building 30 miles of new trails in the nearby Gunpowder Falls State Park and Prettyboy Reservoir watershed, nominally under the auspices of the Sierra Club. (He also belonged to the Appalachian Mountain Club and Mountain Club of Maryland.)
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From page 245... ...
M A R T I N G L O V E R L A R R A B E E 245 bath from the tank of his upstairs toilet. A long piece of thin plastic tubing dripped just fast enough to balance evaporation (and splashing by the birds)
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From page 246... ...
The effects of circulatory arrest and oxygen lack on synaptic transmission in a sympathetic ganglion.
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From page 247... ...
Effects of a nerve-growth factor, embryo age, and metabolic inhibitors on growth of fibres and on synthesis of ribonucleic acid and protein in embryonic sympathetic ganglia.
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From page 248... ...
32:283. 1980 Metabolic disposition of glucose carbon by sensory ganglia of 15 day-old chicken embryos, with new dynamic models of carbohydrate metabolism.
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From page 249... ...
M A R T I N G L O V E R L A R R A B E E 249 1996 Partitioning of CO2 production between glucose and lactate in excised sympathetic ganglia, with implications for brain.
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