Dietary Reference Intakes The Essential Guide to Nutrient Requirements (2006) / Chapter Skim
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Pages 196-201
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From page 196... ...
TABLE 1 Dietary Reference Intakes for Biotin by Life Stage Group DRI values (mg/day) AIa ULb Life stage groupc 0 through 6 mo 5 7 through 12 mo 6 1 through 3 y 8 4 through 8 y 12 9 through 13 y 20 14 through 18 y 25 19 through 30 y 30 31 through 50 y 30 51 through 70 y 30 > 70 y 30 Pregnancy £ 18 y 30 19 through 50 y 30 Lactation £ 18 y 35 19 through 50 y 35 a AI = Adequate Intake.
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From page 197... ...
PART III: BIOTIN 197 BIOTIN B iotin functions as a coenzyme in bicarbonate-dependent carboxylation reactions. It exists both as free biotin and in protein-bound forms in foods.
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From page 198... ...
DRIs: THE ESSENTIAL GUIDE TO NUTRIENT REQUIREMENTS 198 DETERMINING DRIS Determining Requirements Since data were insufficient to establish an EAR and thus calculate an RDA, an AI was instead developed. The AIs for biotin are based on extrapolation from the amount of biotin in human milk.
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From page 199... ...
PART III: BIOTIN 199 timated in diets. Although biotin is widely distributed in natural foods, its concentration significantly varies.
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From page 200... ...
DRIs: THE ESSENTIAL GUIDE TO NUTRIENT REQUIREMENTS 200 EXCESS INTAKE There have been no reported adverse effects of biotin in humans or animals. Toxicity has not been reported in patients given daily doses of biotin up to 200 mg orally and up to 20 mg intravenously to treat biotin-responsive inborn er rors of metabolism and acquired biotin deficiency.
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From page 201... ...
KEY POINTS FOR BIOTIN Biotin functions as a coenzyme in bicarbonate-dependent 3 carboxylation reactions. Since data were insufficient to establish an EAR and thus 3 calculate an RDA, an AI was instead developed.
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