Fluoride in Drinking Water A Scientific Review of EPA's Standards (2006) / Chapter Skim
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Appendix D Comparative Pharmacokinetics of Rats and Humans
Appendix D Comparative Pharmacokinetics of Rats and Humans
Pages 442-446
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From page 442... ...
In another chronic experiment with Sprague-Dawley rats, plasma/water fluoride ratios decreased from 4.2 at 2 months to 1.5 at 18 months (Whitford and Birdsong-Whitford 2000; G Whitford, University of Georgia, personal communication, June 2, 2004)
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From page 443... ...
Birdsong-Whitford 1995 NTPa 1990 2000b Strain Sprague-Dawley F344/N Sprague-Dawley Sprague-Dawley Sampling 3, 6, 12, 18 months 103 weeks 99 weeks 2, 6, 12, 18 months Start time Weanling Weanling 6 weeks 6 weeks Sex M M, F M, F Water fluoride, 0, 5, 15, 50 0, 11, 45, 79 -- 1, 10, 100 mg/L Diet fluoride, 1.2 8 Various ppm Bone samples Femur, vertebra Humerus Radius, ulna Femur, radius, calvarium aThe NTP results were published by Bucher et al.
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From page 444... ...
444 APPENDIX D 90 00 80 00 70 00 NTP (103 wks) Whitford (18 mo)
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From page 445... ...
APPENDIX D 44 TABLE D-2 Comparative Uptake of Fluoride Between Humans and Rats Bone Versus Water Bone Versus Dosea Zipkin/NTP 24 to 25b 42 Zipkin/Dunipace 10 to 11b 20 Zipkin/Maurer NA 40 aUse of the crude and adjusted human models produces very similar results (difference of less than 1)
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From page 446... ...
446 APPENDIX D 10000 9000 8000 NTP 7000 Dunipace ash) NTP regression 6000 Dunipace regression (ppm 5000 F Zipkin crude 4000 Zipki n adjusted Bone 3000 Maurer 2000 Maurer-est 1000 0 0 1 2 3 4 5 Estimated dose (mg/kg/day)
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