Funding Biomedical Research Programs Contributions of the Markey Trust (2006) / Chapter Skim
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Appendix C Site Visit Reports, Telephone Interviews, and Letter Reports Lucille P. Markey Charitable Trust Small Research Program Grant Awards
Appendix C Site Visit Reports, Telephone Interviews, and Letter Reports Lucille P. Markey Charitable Trust Small Research Program Grant Awards
Pages 87-116
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From page 87... ...
Initial funding began in 1994 and continued until 1997. Impact of Markey Funds Markey funds were used to implement a new developmental biology program at Baylor College of Medicine, directed by Hugo Bellen.
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From page 88... ...
The former was directed to the activities of the structural biology and biochemistry group under the direction of Laura Davis; the latter supported the research of Lizabeth Hedstrom, a professor of biochemistry. Impact of Markey Funds Gregory Petsko was the principal investigator of the Markey award.
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From page 89... ...
The goal of this project is to use site-directed mutagens to analyze the conformation change that occurs when trypsinogen is active and inactive conformations of trypsinogen and trypsin are assessed on order to define the forces that govern protein conformational stability. BROWN UNIVERSITY PROGRAM IN MOLECULAR AND CELL BIOLOGY OCTOBER 2002 History and Background of Markey Funding In 1990 Brown began developing a program focused on Molecular and Cell Biology of Disease.
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From page 90... ...
Overall the Markey grant supported 66 predoctoral students, 15 M.D./Ph.D. students, and 17 postdoctoral fellows who engaged in research in this program.
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From page 91... ...
She will initiate NMR analyses of the PU.1 transcription factor and additional studies of the molecular structures of other DNA-binding proteins It is important to note that although the overall level of funding that the Burnham Institute received was not large compared to funding received by other recipients, it represented 10 percent of the total revenue for 1991. The Burnham staff stressed that the Markey funding was crucial for three reasons.
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From page 92... ...
Third, the Markey Trustees were flexible with the timing of the release of funds, allowing funds to be shepherded until they could be used efficiently. CARNEGIE MELLON UNIVERSITY DEPARTMENT OF BIOLOGICAL SCIENCES SEPTEMBER 2000 History and Background of Markey Funding In 1985 Carnegie Mellon submitted a proposal from the Department of Biological Sciences for two purposes: (1)
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From page 93... ...
Also in 1986 Cold Spring Harbor received $863,500 from Markey Trust, which was seed money to begin a program in structural biology. They recruited two structural biologists and three crystallographers (and their respective equipment)
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From page 94... ...
Stillman, the greatest impact of the Markey funds was to enable Cold Spring Harbor to invest in good scientists early in their careers and give them the needed boost to get their research underway. Cold Spring Harbor used Markey funds to help support the salaries and operating expenses of new scientists until they were able to obtain sufficient research grants to maintain their own research programs.
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From page 95... ...
Impact of Markey Funds In 1994 the Markey Trust awarded Cornell $1.2 million, which were often combined with other funds to accomplish the program's goals. The Markey funds were used to partially support several major pieces of equipment, specifically a 600 MHz NMR spectrometer, and two X-ray detector systems and computers for the synchrotron beam lines at Cornell High Energy Synchrotron Source (CHESS)
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From page 96... ...
He stated, "In my experience, most foundations want full ownership. The Markey funds were used to partially support several pieces of equipment." ELEANOR ROOSEVELT INSTITUTE FOR CANCER RESEARCH STUDIES ON THE MOLECULAR GENETICS OF CELLULAR PHENOMENA SEPTEMBER 2001 History and Background of Markey Funding Although the Eleanor Roosevelt Institute is an independent entity under its own Board of Trustees, it is housed in the Department of Biophysics at the University of Colorado Medical School, with Dr.
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From page 97... ...
FLORIDA STATE UNIVERSITY PROGRAM IN STRUCTURAL BIOLOGY APRIL 2002 History and Background of Markey Funding In 1988, Florida State University submitted a proposal to Markey to initiate a program in structural biology. The proposal included start-up funds for eight new faculty, capital equipment for ongoing research and for a new x-ray crystallography unit, initial support for research assistants, and construction funds to add 12,000 square feet of new research space.
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From page 98... ...
The structural biology 500 MHz NMR spectrometer was acquired, in part, with Markey funds and is maintained with Markey funding. This enables faculty from the structural biology program supported by Markey funds almost exclusive use of the NMR.
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From page 99... ...
The largest component of the Markey proposal is for new scientists, primarily junior investigators, for supplies and equipment. Impact of Markey Funds The Markey Trust awarded Fox Chase $4.0 million in early 1991.
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Their research required significant numbers of mice. OREGON HEALTH SCIENCES UNIVERSITY VOLLUM INSTITUTE FOR ADVANCED BIOMEDICAL RESEARCH MAY 2002 History and Background of Markey Funding The Vollum Institute of the Oregon Health Sciences University was made possible by a gift of $23 million from Mr.
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From page 101... ...
There is some tension between the University leadership and the Institute director. The request to the Markey Trust from the Institute's director was for the support of fundamental genetic, cellular and molecular studies of the basis of drug addiction.
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From page 102... ...
SALK INSTITUTE FOR BIOLOGICAL STUDIES PROGRAM IN STRUCTURAL BIOLOGY AUGUST 2002 History and Background of Markey Funding The Salk Institute requested to develop their structural biology program. Of the total request, the majority of funding was to be used to renovate the space designated for the program's use, and the balance was to cover the cost of x-ray and computational equipment.
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From page 103... ...
The Salk staff stressed the importance of Markey funding as support from federal agencies was not available to purchase expensive equipment and to renovate space in which to locate it. Without the Markey funding, the director declared, Salk would not have been able to establish its structural biology program.
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From page 104... ...
Finally the entire group was awarded three awards for over $3.5 million. Consequently, over $7 million of additional extramural support has been made possible by the support of the Markey Trust.
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From page 105... ...
Ultimately, the Markey Trust awarded a grant in the amount of $1.6 million. Impact of Markey Funds The University of California, Davis, Center for Comparative Medicine is a cooperative, interdisciplinary research center co-sponsored by the Schools of Medicine and Veterinary Medicine.
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From page 106... ...
Impact of Markey Funds The Center for Molecular Biology of RNA, which received $2.5 million from the Markey Trust, was established in 1992 and has developed into a thriving research community with an international reputation for RNA research. The Center has grown from five to eight faculty, from the Departments of Biology, Chemistry & Biochemistry, and Computer Sciences.
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From page 107... ...
The program was directed towards merging molecular and structural biology in an interactive program. Although this theme is widely accepted now, it was quite novel in the 1980s.
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From page 108... ...
This is, I think, a reflection not only of the trustees and of the excellent staff, but of the outstanding and enlight ened leadership of Bob Glaser and Louis Hector. UNIVERSITY OF COLORADO, BOULDER CENTER FOR MAMMALIAN BIOLOGY SEPTEMBER 2001 History and Background of Markey Funding The University of Colorado, Boulder, requested funding for a new Center for Mammalian Biology within the Department of Molecular, Cellular, and Developmental Biology.
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From page 109... ...
The 3-year Markey award of $1.5 million, made in 1994, was to provide laboratory space and equipment for six investigators, develop a mouse facility, and add a conference facility. Impact of Markey Funds The Department of Molecular, Cellular, and Developmental Biology is undergoing a doubling in size of faculty and research space.
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From page 110... ...
Matthews, the Markey award was spent as follows: Major Equipment 40% Recruiting New Faculty 36% Core Facilities 12% Individual Labs 12% The Impact of Markey Funding The Center for Macromolecular Biology is now firmly established at the University of Oregon. Of the initial faculty recruited for the Center, two have since left the institution.
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From page 111... ...
UNIVERSITY OF ROCHESTER THE NEUROSCIENCES INSTITUTE OCTOBER 2001 History and Background of Markey Funding The Lucille P Markey Charitable Trust awarded a 6-year grant of $4 million to the University of Rochester to help develop the Neurosciences Institute.
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From page 112... ...
These senior investigators continue to support the research efforts of many junior investigators and use a majority of their resources supporting projects that provide faculty development for these junior investigators to expand their research capacities and expand collaborative ties. Finally, the Institute has supported six pilot research programs utilizing Markey funds.
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From page 113... ...
Unfortunately, the Center is merely a shell at this time. The grant was significant in the history of the university because prior to Markey funding there was no structural biology.
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From page 114... ...
Although the Markey funds were used in combination with other grants to develop the Center and its facilities, the impact of the Markey award appears to have been substantial. Not only is the Center name "The Markey Center for Molecular Genetics," but Dr.
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From page 115... ...
APPENDIX C 115 this grant. It is apparent that the University of Vermont nurtures the life sciences and invests in new and emerging technologies.
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