Battling Malaria Strengthening the U.S. Military Malaria Vaccine Program (2006) / Chapter Skim
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to conduct a programmatic review of the military Plasmodium falciparum malaria vaccine research and development program. All four species of the genus Plasmodium that cause human malaria present a threat, but P
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The malaria vaccine research and development programs at these institutions are referred to jointly in this report as the MIDRP Malaria Vaccine Program. Malaria Vaccine Progress to Date The MIDRP Malaria Vaccine Program is a large proportion of the global effort and has been involved in about half of all the vaccine candidates that have been or are currently in development, including several of the candidates that have progressed to clinical efficacy trials in endemic areas.
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However, as research progresses, the number of candidate products must be limited by dropping those that perform less well. The MIDRP Malaria Vaccine Program should aggressively move into clinical trials to test specific vaccine products, and select two to three leads at phase 1 and one at phase 2 for each strategy.
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Implementation of the current recommendations should be assured by the establishment of a malaria vaccine program transition team for the period required to carry out the JTF-MV reorganization and constitution of the scientific advisory board.
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military personnel deployed to malaria-endemic areas of the world, and current malaria prevention and control methods are indisputably inadequate. Recommendation 2.2: The DoD should formally acknowledge the high cost of developing any new vaccine and the fact that the MIDRP Malaria Vaccine Program is severely underfunded in relation to the goal.
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The current incomplete understanding of the mechanisms of protective immu nity to malaria in humans constitutes a barrier that impedes malaria vaccine development. Organization and Management of the Program Recommendation 5.1: The MIDRP Malaria Vaccine Program, currently composed of two separate entities -- WRAIR and NMRC, should be inte grated into a unified organizational entity (Joint Task Force for Malaria Vaccine [JTF-MV]
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Recommendation 5.4: The JTF-MV program for vaccine development should have an external senior expert advisory group (scientific advisory board) that conducts yearly face-to-face meetings to provide external review and evaluation of the scientific program, and also gives ongoing advice in a timely manner.
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The DoD should respond to the lack of sufficient depth of human resources to carry through current objectives with increased resources to carry out the workforce plan. Recommendation 5.8: Sufficient funding should be made available to sup port the infrastructure to produce pilot-lot formulations of MIDRP malaria vaccine candidates in-house at the pilot production plant at Forest Glen (an invaluable part of the MIDRP Malaria Vaccine Program)
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