Veterans and Agent Orange Update 2006 (2007) / Chapter Skim
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10 Research Recommendations
10 Research Recommendations
Pages 699-704
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From page 699... ...
• There is a need for new animal models to elucidate mechanisms of diseases and disease progression. The committee believes that experimental research in the mechanisms that underlie human health outcomes (particularly cardiovascular disease)
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From page 700... ...
The committee recognized that, within the study populations reviewed in preparing Update 2006, the values of serum components and specific health outcomes may be interrelated, including hypertriglyceridemia, type 2 diabetes mellitus, hypertension, and ischemic heart disease. The first three of those outcomes are key criteria for the diagnosis of metabolic syndrome, and the fourth is a major consequence of it.
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From page 701... ...
This work is particularly relevant in assessing health outcomes in offspring among a largely male service population. The plausibility of birth defects arising from parental exposure, especially from paternal exposure, merits a careful review in light of newly hypothesized mechanisms (such as heritable forms of gamete imprinting)
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From page 702... ...
The committee also notes that future analyses of health outcomes in those and other important study populations should be as specific as possible because generic findings, such as for "all respiratory outcomes," are not useful in addressing this committee's charge of determining associations of herbicide exposures with specific health conditions. • VA should evaluate possibilities for studying health outcomes among Vietnam-era veterans by using the existing administrative and health services databases.
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From page 703... ...
The present committee recommends that the model be incorporated into new epidemiologic studies where feasible, as is being investigated by a newly convened IOM committee, the Committee on Making Best Use of the Agent Orange Reconstruction Model. • Studies of the Vietnamese population would be worthwhile.
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From page 704... ...
2005. Audit of VA Acquisition Practices for the National Vietnam Veterans Longitudinal Study (Report No.
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