Challenges and Opportunities in Using Residual Newborn Screening Samples for Translational Research Workshop Summary (2010) / Chapter Skim
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1 Introduction
1 Introduction
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Today most states require that all infants be screened for at least 29 of the 30 conditions1 recommended by the Secretary's Advisory Committee on Heritable BOX 1-1 Definition Translational Research Defined here as the use of residual dried blood spots in basic laboratory, clinical, or public health research in order to transform the relevant findings into clinical applications and reduce disease burdens. 1 SCID was officially added to the Recommended Uniform Screening Panel core conditions on May 21, 2010.
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Many of these uses are directly related to improving screening programs, such as the development of new methods and tests. But over the years, researchers have become increasingly aware that residual dried blood spots from newborn screening programs constitute an unparalleled resource for public health and biomedical research.
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As researchers continue to explore the biological bases of diseases and disease susceptibilities, these issues will only become more significant. Because fundamental questions concerning newborn screening can be examined within the context of specific public health programs, newborn screening offers lessons that can be applied much more broadly in health care.
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