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Evaluation of a Site-Specific Risk Assessment for the Department of Homeland Security's Planned National Bio- and Agro-Defense Facility in Manhattan, Kansas (2010) / Chapter Skim
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4 Evaluation of Design Plans and Personnel Preparedness
Pages 51-56

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From page 51...
... generated by NBAF operations. With respect to the immediate infrastructure for the containment, collection, and treatment of residuals generated by the NBAF's proposed laboratory and suite of operations, the committee has confidence in the experience and the ability of the civil, environmental, and architectural engineering teams to design systems that meet or exceed the specialty residual decontamination challenges for this unique facility.
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From page 52...
... Department of Agriculture's Agricultural Research Service facility design standards strongly recommend backup HEPA filter units to allow filter changes without disrupting research (USDA-ARS, 2002; CDC, 2009)
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From page 53...
... The decision to omit parallel redundant series of HEPA filters was made in contravention of both the BMBL and USDA ARS Facility Design Standards strongly recommending both HEPA filters in series and parallel redundant systems for BSL-3Ag and BLS-4 spaces. Appendix C of the SSRA states that "the [DHS-convened qualitative risk assessment subject matter expert]
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From page 54...
... An example would be to reduce the square footage of completed BSL-3Ag holding rooms by abbreviating the length of stainless steel ductwork initially installed for the HVAC and stubbing the plumbing and electrical installations that lead to the containment rooms until funding is available for completing the project. That solution has been applied to comparable containment facilities, does not compromise safety, and ensures that the facility can accommodate future increased capacity to fulfill the NBAF mission.
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From page 55...
... The NBAF will also inevitably expand its mission to move further into the modern world of molecular virology, molecular immunology, molecular pathogenesis and pathophysiology, molecular vaccinology, and therapeutics -- fields of biomedical science from which disease prevention and control strategies are to emerge. Federal and International Regulations It is expected that further federal regulations, guidelines, or standards are forthcoming regarding the qualification, certification, or accreditation of staff who work at BSL-3 and BSL-4 containment levels.
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From page 56...
... Fifth Edition. Available online at http://www.cdc.gov/biosafety/publications/bmbl5/BMBL.pdf [accessed July 26, 2010]
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Key Terms

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  • biocontainment facilities
  • human error
  • redundant hepa

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  • similar charters
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  • hepa exhaust
  • foreign animal

  • value engineering
  • redundant bank
  • redundant series
  • animal pathogens
  • design standards

  • filter loading
  • design guidelines
  • maintenance information
  • square footage
  • challenges associated

  • primary bank
  • special procedure
  • projected performance
  • health agency
  • standards strongly

  • strongly recommend
  • agricultural research
  • filter banks
  • parallel hepa
  • hepa filter


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