Evaluation of a Site-Specific Risk Assessment for the Department of Homeland Security's Planned National Bio- and Agro-Defense Facility in Manhattan, Kansas (2010) / Chapter Skim
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1 Introduction
1 Introduction
Pages 9-18
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and will presumably lead in developing effective vaccines, therapeutics, and diagnostics for animal diseases, including genomics related to threat agents and zoonotic diseases. 2 It will also provide critical diagnostic capacity for identifying emerging foreign 1 A foreign animal disease is an animal disease caused by an agent that does not occur naturally in the United States.
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the date on which the Secretary of Homeland Security submits to the Committee on Appropriations of the Senate and the House of Representatives a site-specific bio-safety and biosecurity mitigation risk assessment, which includes an integrated set of analyses using plume modeling and epidemiologic impact modeling, to determine the requirements necessary to ensure safe operation of the National Bio- and Agro-defense Facility at the approved Manhattan, Kansas, site identified in the January 16, 2009, record of decision published in Federal Register Vol. 74, Number 11, and the results of the National Academy of Sciences' review of the risk assessment as described in paragraph (b)
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until the Secretary of Homeland Security undertakes a site-specific biosafety and biosecurity mitigation risk assessment for the Manhattan, Kansas site. Once DHS completes the risk assessment, the Congressional language mandates that the National Academy of Sciences provide an independent evaluation of the DHS analyses.
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The committee believed that in planning for the NBAF and preparing for its eventual operation, the SSRA would need to inform about the potential risks of pathogen escape so that plans could be appropriately developed to reduce risk (such as modifications in facility engineering design and operation plans) and mitigate potential consequences.
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During the open session of the meeting, the committee raised questions about the SSRA, and it submitted additional questions to DHS shortly thereafter. DHS delivered follow-up letters on July 28 and August 26, 2010; the latter follow-up letter provided a revised economic analysis, revised version of the SSRA's chapter 5 with edits noted, and a revised discussion of risk posed by high-velocity winds (both follow-up letters are included in an appendix to the SSRA)
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This final report provides an evaluation of the SSRA and attempts to fulfill its two tasks: informing whether the risks were adequately and validly characterized for locating the NBAF in Manhattan, Kansas, so that Congress can make an informed judgment on the obligation of NBAF construction funds; and identifying ways for DHS to improve the biosafety and mitigation plans to ensure safe operations for the NBAF. NEW CAPABILITIES OF AND RISKS POSED BY THE NATIONAL BIO- AND AGRO DEFENSE FACILITY Foot-and-Mouth Disease Virus Research on the Mainland The plan to locate the NBAF in Manhattan, Kansas, reflects an important change in both policy and philosophy related to conducting foreign animal disease programs that use infectious (live)
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and the National Centre for Foreign Animal Disease (in Winnipeg) have set the standard for biocontainment of research and training activities involving dangerous zoonotic pathogens in large animals.
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. The proposed site of the NBAF will be on the KSU campus immediately adjacent to the recently constructed Biosecurity Research Institute (BRI)
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2009. Record of Decision for the National Bio- and Agro-Defense Facility Environmental Impact Statement: Department of Homeland Security, Science and Technology Directorate.
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2005. Animal Health at the Crossroads: Preventing, Detecting, and Diagnosing Animal Diseases.
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