Generating Evidence for Genomic Diagnostic Test Development Workshop Summary (2011) / Chapter Skim
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1 Introduction
1 Introduction
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However, much of the evidence surrounding the clinical value and utility of these tests has not been sufficient enough for clinical practitioners to broadly embrace many of these in practice. A major impediment to the integration of these genomic tests into routine health care is the lack of an adequate evidence base linking the use of genomic diagnostic tests to health outcomes.
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Genetic tests are still in use today, Leonard said, but the focus has shifted to genomic tests, which are complex testing algorithms of multiple genetic variants, multiple genes, or gene expression patterns. Genomic tests are used for diagnosis as well as for therapeutic selection, dosing, prognosis, and residual disease detection.
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outcomes No evidence that tests Genomic tests for ovarian cancer EGAPP affect outcomes in asymptomatic women Abbreviations: AHRQ (Agency for Healthcare Research and Quality) , EGAPP (Evaluation of Genomic Applications in Practice and Prevention)
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Approaches for evidence generation are discussed in Chapter 3. Chapters 4 and 5 examine ways to overcome the barriers to evidence generation and strategies for moving forward.
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