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Letter Report
Letter Report
Pages 1-9
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The committee was charged with reviewing a proposed approach to preparing risk assessments for the new biocontainment laboratory at the base. Enclosed is the committee's first letter report on the Army contractor's proposed approaches to conducting the risk assessment.
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Technical input could include, but not be limited to, a review of the proposed work plan for preparing risk assessments, as well as information on the selection of pathogen agents, scenarios, and models to be used in the risk assessments. If the preliminary model results for the quantitative risk assessment and the qualitative assessments were available, they would be reviewed.
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In the absence of a formal work plan and preliminary facility designs, it was difficult to assess whether the Army contractor's approach will result in a comprehensive and credible SSRA. Therefore, the committee has approached its task by describing significant critical elements that are important for executing a successful SSRA.
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. SPECIFIC FINDINGS ON THE SSRA BRIEFING Selection of Agents The SSRA briefing listed eight organisms (Bacillus anthracis; Ebola, Marburg; Francisella tularensis; Brucella; arboviruses (three)
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. Most biocontainment facilities establish review processes to consider these types of emerging threats.
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Dry-Use Scenarios specifically follow the use, transport, and fate of all agents or agent countermeasures that are handled in a desiccated state. Probabilistic Safety Analyses consider possible natural hazards, human accidents, engineering accidents (internal and external)
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; and (3) the formal methods to conduct a probabilistic safety analysis (e.g., cascading, parallel, and series failures; natural hazards; and loss of key utilities)
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. The committee recommends that the Army contractor perform probabilistic safety analyses for a wide variety of events (e.g., natural events, deliberate sabotage, loss of key utilities, cascading failures, parallel or series failures, and aircraft crashes)
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At the meeting and in the past, the community members have repeatedly requested that risk evaluations for laboratory facilities at Fort Detrick include a comparative risk assessment with alternative locations, such as remote or sparsely populated areas. The NRC committee that evaluated the Army's USAMRIID facility at Fort Detrick was supportive of conducting such an exercise because it would help "[distinguish between]
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