Biographical Memoirs Volume 59 (1990) / Chapter Skim
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Frederic C. Bartter
Frederic C. Bartter
Pages 2-25
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Ye ~ ~ Jim.,
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scientific stature of each through his ability to stimulate, guide, and enhance the talents of others. EARLY LIFE George Bartter, an Anglican minister from England, and his wife, Frances Buffington, an American teacher, had two children—George and Frederic both born in Manila and raised in the remote mountain village of Baguio, Philippine Islands, which became the family home.
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The paper concerned plasma volume and the speed with which plasma is reconstituted after donation of blood, the control of blood volume being an important topic throughout his subsequent career. The Public Health Service then assigned him to the Pan American Sanitary Bureau to investigate the physiology of parasitic diseases, one result of which was a pioneering study of the treatment of onchocerciasis.
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During his years with Albright, Bartter developed a number of interests that would continue throughout his career: the metabolic effects of ACTH in man, parathyroid pathophysiology ant! bone metabolism, the control of blood volume in disease, and the metabolic effects of androgens, estrogens, and adrenocortical steroids in various disorders.
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secretion, they reasoned, the pituitary secretes excessive quantities of ACTH leading to excessive secretion of other classes of adrenal steroids by the adrenals themselves. Bartter and Albright proved their thesis by treating affected patients with cortisone to correct the hypersecretion of virilizing steroids undoubtedly the single greatest stroke of genius in understanding and controlling adrenal hyperplasia.
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The low plasma renin values measured in several patients with proven adrenal hyperplasia suggested that, in these patients, all adrenal tissue responds to a tropic stimulus other than ACTH or the renin-angiotensin system. This, too, continues to be an active field!
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From its immediate impact upon medicine, Bartter's description of inappropriate ADH secretion was perhaps his most · , mportant discovery. During the last decade of his scientific career, Bartter focused on the control of blood pressure and the derangements that underlie the hypertensive disorders of man—a line of investigation that continued after his 1978 move to the University of Texas Health Science Center in San Antonio and was cut short by his untimely death.
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on the symptoms and treatment of mushroom poisoning. Following Czech reports of lipoic acid as an antidote for Amanita mushroom poisoning, Bartter and Charles Becker of the University of California, San Francisco obtained an
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HONORS Fret] Bartter was a member of numerous professional and scientific societies, including the Endocrine Society, the American Society for Clinical Investigation, the Association of American Physicians, the Royal Society of Medicine, the Royal College of Physicians of London, the Peripatetic Club, and the National Academy of Sciences, to which he was elected!
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for his memorable contribution to the understanding of hormonal regulation of renal function and salt and water homeostasis." Bartter was also asked to give many honorary lectures, including the 1980 Arthur B Corcoran Award of the High Blood Pressure Council and the 1982 Fuller Albright Lecture of the Peripatetic Club.
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Howard University 1960-1978 Associate Professor and Clinical Professor of Medicine, Georgetown University 1978-1983 Professor of Medicine, University of Texas Health Science Center, San Antonio, and Associate Chief of Staff for Research, Audie L Murphy Memorial Veterans Administration Hospital, San Antonio MEMBERSHIPS Endocrine Society Laurentian Hormone Conference American Society for Clinical Investigation Association of American Physicians Salt and Water Club
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FREDERIC C BARTTER Peripatetic Society American Physiological Society Royal Society of Medicine-Endocrinology Section Royal College of Physicians of London National Academy of Sciences Alpha Omega Alpha 13
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Carroll. The effects of adrenocorticotropic hormone and cortisone in the adrenogenital syndrome associated with congenital adrenal hyperplasia: An attempt to explain and correct its disordered hormonal pattern.
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~ syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone.
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Tassell. Further observations on hyponatremia and renal sodium loss probably resulting from inappropriate secretion of antidiuretic hormone.
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Gill, fir. Studies on taste thresholds in normal man and in patients with adrenal cortical insufficiency: The role of adrenal cortical steroids and of serum sodium concentration.
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Gill, Jr. Effect of human renin on aldosterone secretion rate in normal man and in patients with the syndrome of hyperaldosteronism, juxtaglomerular hyperplasia and normal blood pressure.
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Easton. Bilateral adrenal hyperplasia as a cause of primary aldosteronism with hypertension, hypokalemia and suppressed renin activity.
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Studies on the deficiency of 21-hydroxylation in patients with congenital adrenal hyperplasia.
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Pomeroy. Ewing's sarcoma as a cause of the syndrome of inappropriate secretion of antidiuretic hormone.
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Evidence for endogenous LH suppression in a man with bilateral testicular tumors and congenital adrenal hyperplasia.
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Factors influencing blood pressure in salt-sensitive patients with hypertension.
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Orth. The response of plasma immunoreactive adrenocorticotropin, beta-endorphin/beta-lipotropin, gamma-lipotropin and cortisol to experimentally induced pain in normal subjects.
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