Biographical Memoirs Volume 59 (1990) / Chapter Skim
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Manfred Martin Mayer
Manfred Martin Mayer
Pages 256-281
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From page 257... ...
He uncovered the first indications of the enzymatic cleavage of one complement protein by another, leading to our eventual understan(ling of the sequential interaction and function of the eighteen proteins of the complement system. He appreciatec} that cytolysis by complement is due to the insertion of hydrophobic complement peptides into the lipid bilayer of biomembranes and formation of transmembrane channels.
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From page 258... ...
His background in physical chemistry fit well with Heiclelberger's organic chemical background and approach, and he was very comfortable in this laboratory that also container! Forest Kendall and had just trained EIvin Kabat.
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From page 259... ...
For a number of years, EIvin Kabat and Manfrect Mayer met virtually every weekend in one another's apartments to react aloucl and revise every word of the proposed text. Heiclelberger also react it and ultimately prepared the introduction to the volume.
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From page 260... ...
Finally, Herbert Rapp was analyzing the different functions of rabbit antibodies of different immunoglobulin classes and, with Manfred, was beginning to develop a mathematical basis for the analysis of the reaction sequence. Their work resulted in the conclusion that the "third component of complement" was not a single substance but, based upon its behavioral characteristics as defined in mathematical terms, represented multiple substances a conclusion subsequently substantiated by the identification of five component proteins.
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From page 261... ...
his colleague Robert Nelson developed the Tr~ponema pallidum immobilization test for syphilis an important contribution to clinical medicine capable of eliminating false-positive reactions. At that time the conventional test for syphilis yielder!
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From page 262... ...
biochemistry of the complement field were recognized in 1969 by an honorary degree in medical science from the ~ohannes Gutenberg University of Mainz, Germany; in 1974 by the Karl Lancisteiner Award of the American Association of Blood Banks; in 1979 by election to the presidency of the American Association of Immunologists; and in 1982 by the Gairciner Foundation International Award. In ~ 953 he shared with Robert Nelson the Kimble Award for MethocIology for the development of the ~ pallidum immobilization test.
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From page 263... ...
MANFRED MARTIN MAYER 263 established results ant! their implications.
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From page 264... ...
An admirer of beauty in art, music, and science, Manfred Mayer was a true role mode] of the scientist-teacher.
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From page 265... ...
MANFRED MARTIN MAYER HONORS AND DISTINCTIONS PROFESSIONAL AND ACADEMIC POSITIONS 265 1938-1942 Laboratory Assistant in Immunochemistry, Columbia University 1942-1945 Member of the Scientific Staff, Project of the Office of Scientific Research and Development, Columbia University 1946 Instructor in Biochemistry, Columbia University 1946-1947 Assistant Professor of Bacteriology, Johns Hopkins University School of Hygiene and Public Health 1948 1957 1960 LEARNED SOCIETIES Associate Professor of Microbiology, Johns Hopkins University School of Hygiene and Public Health Acting Chairman, Department of Microbiology, Johns Hopkins University School of Hygiene and Public Health Professor of Microbiology, Department of Microbiology, Johns Hopkins University of Medicine American Association for the Advancement of Science American Association of Immunologists American Chemical Society American Society of Biological Chemists Biochemical Society National Academy of Sciences Society for Experimental Biology and Medicine HONORARY MEMBERSHIPS Phi Beta Kappa Sigma Xi Collegium Internationale Allergologicum OTHER PROFESSIONAL ACTIVITIES Consultant, United States Public Health Service Consultant, National Science Foundation Consultant, Office of Naval Research Consultant, Plum Island Animal Disease Laboratory, Department of Agriculture Associate Editor, Biological Abstracts
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From page 266... ...
266 BIOGRAPHICAL MEMOIRS Associate Editor, Journal of Immunology Associate Editor, Analytical Biochemistry Associate Editor, Immunochemistry President, American Association of Immunologists Editorial Board, journal of Immunology PRIZES AND AWARDS 1945 Citation, Columbia University, for work in the Division of War Research during World War II 1953 Kimble Award for Methodology 1957 Selman Waksman Lectureship Award 1969 Honorary Doctor of Medical Science, tohannes Gutenberg University, Mainz, Germany 1974 Karl Landsteiner Award, American Association of Blood Banks 1976 Albion 0. Bernstein Award, Medical Society of the State of New York 1982 Gairdner Foundation International Award, Toronto, Canada
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From page 267... ...
Normal human stromata as antigens for complement fixation in the sera of patients with relapsing vivax malaria. Science, 100:359.
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From page 268... ...
Quantitative studies on complement fixation.
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From page 269... ...
Studies on the role of Ca++ and Mg++ in complement fixation and immune hemolysis.
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From page 270... ...
Studies on the role of Ca+ + and Mg+ + in complement fixation and immune hemolysis.
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From page 271... ...
II. The reaction between EAC'1,4 and C'2: Evidence on the single site mechanism of immune hemolysis and determination of C'2 on an absolute molecular basis.
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From page 272... ...
Mechanism of action of guinea pig complement. In: Mechanism of Cell and Tissue Damage Produced by Immune Reactions (Second International Symposium on Immunopathology, Brook Lodge, Michigan)
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From page 273... ...
Fragmentation of guinea pig complement components C'2 and C'3c. In: Protides of the Biolog~cal Fluids ( 1 5th Annual Colloquium)
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From page 274... ...
Specific cytolytic activity of lymphocytes: Effect of antibodies against complement components C2, C3, and C5.
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From page 275... ...
The molecular dimensions of mitogenic factor from guinea pig lymph node cells.
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From page 276... ...
Increased ion permeability of planar lipid bilayer membranes after treatment with the C5b-9 cytolytic attack mechanism of complement.
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From page 277... ...
On the mechanism of membrane damage by complement: The effect of length and unsaturation of the acyl chains in liposomal bilayers and the effect of cholesterol concentration in sheep erythrocytes and liposomal membranes.
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From page 278... ...
Membrane damage by a toxin from the sea anemone Stoichactts helianthus.
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From page 279... ...
On the size, heterogeneity and molecular composition of the transmembrane channels produced by complement. In: Biological Response Mediators and Modulators, ed.
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From page 280... ...
Shin. Release of arachidonic acid and formation of oxygenated derivatives following complement attack on macrophages: Role of channel formation.
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