Biographical Memoirs Volume 59 (1990) / Chapter Skim
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Maxwell Mayer Wintrobe
Maxwell Mayer Wintrobe
Pages 446-472
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From page 447... ...
By all accounts, Max was a world leader in hematology, a role attested to by a legion of honors, visiting professorships, memberships and activities in national and international scientific societies, consultantships, editorial responsibilities, and perhaps most importantly—by the large cadre of students who had flocked to be under his tutelage and who themselves went on to be leaders in their medical communities and in academia.
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From page 448... ...
Of his teachers at Manitoba he remembered William Boyct, professor of pathology a flowery and exciting lecturer with a rich Scottish brogue as the most stimulating. But as graduation neared, Max, who had achieved an outstanding record, became increasingly aware of his lack of
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From page 449... ...
THE TULANE YEARS (1927—19304: ANEMIA OF THE SOUTH, NORMAL BLOOD VALUES, THE WINTROBE HEMATOCRIT, AND CORPUSCULAR CONSTANTS In September 1927, Max arrived in New OrIeans, having accepted the offer of an appointment as assistant in medicine at Tulane University from Dean C
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From page 450... ...
Wintrobe's careful observations macle on Tulane medical students and women from Sophie Newcomb College together with observations by Russell Haclen in ClevelancI, Edwin Osgood in Portland, and a few made in Europe served as basic ciata for establishing normality in terms of quantitatively accurate observations. Max's second important contribution was the invention of the Wintrobe hematocrit, which universally replacer!
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From page 451... ...
With the assistance of Dean Bass, Wintrobe was able to journey to Hopkins, see Pearl, and meet Alan Chesney, clean of the Medical School. When searching for a suitable publication for his thesis sometime later, Wintrobe hit upon the review journal Medicine; serendipitously, Chesney was its editor.
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From page 452... ...
from discussions with his many colleagues, including George Minot, Bill Castle, and others of the Boston group. Max's career-Ion" interest in pernicious anemia, for instance, was furthered by his admiration of CastIe's classic experiments, and Castle appropriately authored the foreword to his last book, Hematology, the Blossoming of a Science ~ ~ 985, I )
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From page 453... ...
He clemonstrated that the hematocrit effectively measured erythrocyte seclimentation rate and that, when proper centrifugation was employed, the volume of packed red cells could be ascertained accurately and the mass of leukocytes and platelets roughly approximated. The supernatant plasma was also a convenient medium for determining icterus.
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From page 454... ...
that nonautolyzed yeast in sufficient amounts could induce a hemopoietic response in patients with pernicious anemia. As a house officer, Williams was able to sequester suitable subjects from the eye of Professor Longcope, who was unenthusiastic about the study.
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From page 455... ...
sing to complete the index of the first edition of Clinical Hematology (1942,54. Since the authorities insisted he remain in Baltimore he began studying chemical warfare agents with Professor Longcope and Val Jaeger, then a house officer.
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From page 456... ...
Max instituted a program (later widely emulated) whereby students, house officers, and fellows initially examinec!
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From page 457... ...
During the years when Max served as Utah's founding chairman of medicine he also became an international leacler in his chosen field, well beyond the University confines. He served as a visiting professor throughout the worIcl and receive(1 honors and filled high positions too abundant to mention.
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From page 458... ...
His many other responsibilities included consultantships to the Army, the Atomic Energy Commission, and the World Health Organization; chairmanship of the Advisory Committee of the Leukemia Society; and nine years in various capacities with the American Medical Association's Council on Drugs. From 1964 to 1974, Max served as member and chairman of the Scientific Advisory Committee, Scripps Clinic and Research Foundation, La Volta.
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From page 459... ...
, the Utah group established the pig as a mocle} experimental animal. They defined deficiencies of the vitamin B complex and neurologic lesions but were unable to produce pernicious anemia in the pig.
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Wintrobe continued studies on chemical warfare agents they had begun in Baltimore during World War Il. The effects of nitrogen mustard on hematopoiesis they observed lee!
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From page 461... ...
CLINICAL HEMATOLOGY; PRINCIPLES OF INTERNAL MEDICINE; BLOOD, PURE AND ELOQUENT It would be difficult to overestimate the impact of Clinical Hematology on students, house officers, and hematologists since its initial publication in 1942. Authoritatively written, compendious, heavily and meticulously referenced and indexecI, there is no doubt that it was the premier textbook in hematology of its time.
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From page 462... ...
For the sixth and seventh editions, he served as eclitor-in-chief. Max's final literary efforts sprang from a long-standing interest in medical history.
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From page 463... ...
in 1926, the death sentence of a diagnosis of pernicious anemia hac! just been commuted ant!
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From page 464... ...
It was indeed a golden era and Max Wintrobe was one of its chief architects and ambassadors to the world. Max is survived by his wife, Becky; his (laughter, Susan; and his four grandsons, Andrew, Stephen, Timothy, and Davis!
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From page 465... ...
Medicine, 9: 195. 1931 Hemoglobin content, volume and thickness of the red blood corpuscle in pernicious anemia and sprue and the changes associated with liver therapy.
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From page 466... ...
1939 The antianemic effect of yeast in pernicious anemia.
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From page 467... ...
1941 Attempts to produce pernicious anemia experimentally.
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From page 468... ...
Nitrogen mustard therapy. Use of methyl-big (beta-chloroethyl)
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From page 469... ...
Studies on free erythrocyte protoporphyrin, plasma copper, and plasma iron in protein-deficient and iron-deficient swine.
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From page 470... ...
Blood disorders caused by drug sensitivity.
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From page 471... ...
Baltimore: Johns Hopkins Press.
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From page 472... ...
472 BIOGRAPHICAL MEMOIRS 1980 With others. Blood, Pure and Eloquent.
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