The Unique U.S.-Russian Relationship in Biological Science and Biotechnology Recent Experience and Future Directions (2013) / Chapter Skim
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Appendix C.2: Defense Threat Reduction Agency
Appendix C.2: Defense Threat Reduction Agency
Pages 143-150
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These pilot projects were sited at the State Research Center for Virology and Biotechnology Vector (Koltsovo) and State Research Center for Applied Microbiology (Obolensk)
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The American participants have been generally pleased with opportunities to benefit from the work of Russian researchers, who have quickly mastered new techniques and produced results of considerable interest to the international scientific community. DTRA has committed to continuing engagement with Russian organizations through pursuit of shared scientific interests, recognizing that key Russian ministries do not consider the Department of Defense a legitimate partner in addressing civilian biological concerns.
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o Regulations o Biosafety guidelines o Facility plans o Biosafety and security standards o Biosafety and security upgrades at institutes o Biosecurity event notification o Biosafety event notification • Enhance capabilities to detect events o Sharing of data on especially dangerous pathogens o Reporting laboratory results to responsible officials o Providing human-related reports to WHO o Providing animal-related reports to OIE o Sharing of case data o Reporting epidemiological data o Reporting laboratory results o Personal health data reported to WHO o Animal diseases reported to OIE o Investigations of incidents involving especially dangerous pathogens o Appropriate sample collection o Capabilities to diagnose especially dangerous pathogens o characterization of plant pathogens Strain o Appropriate sample transportation • Sustainability o Testing of trainee test results • Miscellaneous o Credible research results o Contribution to efforts of international scientific community o Biosafety guidelines
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Research Center for Toxicology and Hygienic Regulation of Biopreparations, Serpukhov Project Agreement Date: 06/01/01 Projected End Date: 07/31/05 Budget: $599,000 Key Findings: Genes from small and medium segments of the hantaviral genome were cloned into plasmids. These plasmids were complexed with polyethylenimine (PEI)
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Virus Isolates Circulating in Countries of the Region (ISTC #1291.2) State Research Center of Virology and Biotechnology Vector, Koltsovo Project Agreement Date: 08/01/00 Projected End Date: 10/31/05 Budget: $604,645 Key Findings: A unique variable section in the genome encoded by the L-segment of CCHF was explored as a possible marker for geographically distinct isolates of the virus.
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State Research Center of Virology and Biotechnology Vector, Koltsovo Project Agreement Date: 3/01/01 Project End Date: 3/13/03 Buidget: $1,433,374 (co-funded with Department of Health and Human Services) Key Findings: Utilization of the extensive chemistry capabilities in Russia and the coupling of this technology with the unique testing facilities at Vector have resulted in the identification of a collection of new compounds that show antiviral activities when tested against pox viruses.
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State Research Center of Virology and Biotechnology Vector, Koltsovo Project Agreement Date: 3/01/01 Project End Date: 6/13/03 Cost: $1,336,913 (co-funded with Department of Health and Human Services) Key Findings: This project has made major contributions to understanding the interrelationships of different pox viruses.
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The research aspect of this project has contributed to determinations of the pathogenic and toxic properties of collection strains of fungi responsible for barley and wheat Root Rot, Snow Mold, and Fusarium Head Blight, which could negatively impact Russia's food and agriculture industries. NOTE: Other DOD components such as DARPA, have also supported bioengagement.
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