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Large Simple Trials and Knowledge Generation in a Learning Health System Workshop Summary (2013) / Chapter Skim
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8 The Randomized Evaluations of Accepted Choices in Treatment Trials
Pages 55-58

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From page 55...
... , which is an observational data 1  The views expressed during the keynote address are those of Tjeerd-Pieter van Staa and do not reflect the official policy or position of the Medicines and Healthcare Products Regulatory Agency.
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From page 56...
... Currently, CPRD has records on about 5 million patients, about 8 percent of the patient population served by the National Health Service, and this database is updated monthly. van Staa noted that CPRD uses pseudoanonymized data and can link its data sets to other data sets, such as hospital data, disease registries, and death certificates.
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From page 57...
... A few weeks earlier, for example, van Staa reported that 10 patients had been recruited in a certain practice but that another 260 who could have been recruited were not. Variable recording and coding of health care data, especially across the linked data sets, is another challenge to the REACT trials, as are variations in practice across National Health Service sites.
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From page 58...
... Regarding the sharp ethical distinction between research and clinical practice discussed earlier in the workshop, van Staa posited that research on chronic conditions, such as COPD, would provide a benefit to the individual participant as well as a generalizable benefit, because the participant would continue to have the condition after the trial ends.
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Key Terms

  • accepted choices
  • react trials
  • staa noted
  • clinical practice
  • common treatments

  • simple trials
  • routinely collected
  • informed consent
  • keynote address
  • care data

  • reference van
  • comparative effectiveness
  • reporting oversight
  • million patients
  • oversight imposed

  • major obstacle
  • exacerbations currently
  • staa described
  • views expressed
  • data regularly

  • consent form
  • clinicians prescribe
  • care schedules
  • necessarily representative
  • copd exacerbations

  • controlled trials
  • research governance
  • healthcare products
  • conduct pragmatic
  • uniform patient


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