Skip to main content

Microbial Ecology in States of Health and Disease Workshop Summary (2014) / Chapter Skim
Currently Skimming:

A13 Clinical application of fecal microbiota transplantation in Clostridium difficile infection and beyond--Josbert J. Keller and Els van Nood
Pages 347-355

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 347...
... and Els van Nood 58 Abstract Fecal microbiota transplantation (FMT or donor feces infusion) is effective against recurrent and antibiotic-refractory Clostridium difficile infections (CDI)
Read the entire page →
From page 348...
... With subsequent recurrences, the failure rate of antibiotics gradually increases, and some patients develop chronic relapsing and antibiotic refractory Clostridium difficile infection (Maroo and LaMont, 2006)
Read the entire page →
From page 349...
... seems the only effective alternative available, although unappealing. From 1958 there are more than 500 patients described in case series and case reports reporting successful treatment with FMTs for either antibiotic-associated diarrhea ­ or Clostridium difficile infections (Bakken, 2009; van Nood et al., 2009)
Read the entire page →
From page 350...
... We use a questionnaire, adapted from the questionnaire used for potential blood donors, addressing travel history, sexual behaviour, previous operations, blood transfusions, piercings, and all other interventions that might contribute to carriage of an infectious disease. Any risk of a recently contracted infectious disease that is still
Read the entire page →
From page 351...
... In the future, thoroughly screened standardized frozen stool batches might overcome hurdles related to donor selection. Donor screening is summarized in Table A13-1.
Read the entire page →
From page 352...
... Moreover, a significant reduction in fasting lipid profiles after allogenic fecal therapy was noted, which is in line with previously published data suggesting a direct effect between duodenal lipid uptake and glucose production orchestrated by a gut microbiota-driven brain-gut axis. The efficacy of FMT may be explained by enhanced production of specific short-chain free fatty acid butyrate produced by the infused lean donor feces, which might restores normal fecal physiology by implantation of missing leanfigure flora components.
Read the entire page →
From page 353...
... Concluding Remarks FMT is a treatment modality that is effective in patients with recurrent Clostridium difficile infections. FMT seems safe, but careful donor screening is required.
Read the entire page →
From page 354...
... 2012. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection.
Read the entire page →
From page 355...
... 2012. Fecal micro­ biota transplantation for fulminant Clostridium difficile infection in an allogeneic stem cell transplant patient.
Read the entire page →

Key Terms

  • difficile infection
  • donor feces
  • recurrent clostridium
  • van nood
  • fecal microbiota

  • difficile infections
  • gut microbiota
  • bowel lavage
  • feces infusion
  • bowel flora

  • microbiota transplantation
  • versus vancomycin
  • infectious diseases
  • infectious disease
  • difficile strains

  • disturbed bowel
  • fecal microbiome
  • fecal bacteriotherapy
  • donor screening
  • frozen stool

  • randomised controlled
  • ancomycin orally
  • fidaxomicin versus
  • colonisation resistance
  • gradually increases

  • significant reduction
  • mechanism responsible
  • travel history
  • questionnaire addressing
  • sexual behaviour


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.