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Nonhuman Primates: Standards and Guidelines for the Breeding, Care, and Management of Laboratory Animals; a Report (1968) / Chapter Skim
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APPENDIX I: SUGGESTED STANDARD PROCEDURES FOR DETECTION OF TUBERCULOSIS
Pages 44-48

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From page 44...
... Although there is not complete agreement on universally applicable testing procedures for tuberculosis in primates, or on the species and families within the order Primates that should be routinely tested, the subcommittee members feel that the procedure as presented gives the best possible assurance that an individual or colony is tuberculosis-free. The report is presented as "Suggested Standard Procedures" to encourage further comment by specialists in primate medicine.
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From page 45...
... f There is a considerable difference of opinion regarding the proper interval between tuberculin tests, due largely to inadequate data on the length of time required for an infected animal to become tuberculin-positive. It is the opinion of the committee that the intervals given will be adequate if the testing programs for transient and maintenance colonies are rigorously adhered to.
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From page 46...
... All animals with a positive tuberculin test shall be necropsied and appropriate confirmatory tests shall be performed as outlined in A(2)
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From page 47...
... If compelling reasons exist for maintaining a positive reactor, it must be isolated in an area completely removed from other primates and properly equipped for work with infectious agents, and investigators and caretakers must take effective precautions to prevent transmission to humans or to other primates. Treatment with isoniazid is recommended.*
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From page 48...
... Such animals are usually prolific shedders of tubercle bacilli, so every attempt should be made to prevent their introduction into colonies. A few instances are known where positive tuberculin reactors have appeared in maintenance colonies 6 to 9 months after their introduction into the colony, although tuberculin tests were negative in the intervening period.
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Key Terms

  • laboratory animal
  • maintenance colonies
  • negative tests
  • positive tuberculin
  • testing procedures

  • tuberculin test
  • confirmatory tests
  • nonhuman primates
  • pulmonary tuberculosis
  • animal quality

  • maintenance colony
  • testing program
  • positive reactors
  • suggested standard
  • tuberculin tests

  • infectious agents
  • evidence indicates
  • tubercle bacilli
  • quality standards
  • world monkeys

  • positive reactor
  • properly equipped
  • standard procedures
  • weeks prior
  • prolific shedders

  • colonies maintained
  • remaining animals
  • tuberculin reactors
  • active tuberculosis
  • conditioning colonies


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