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Improving the Efficiency and Effectiveness of Genomic Science Translation Workshop Summary (2014) / Chapter Skim
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6 Strategies for Change
Pages 39-44

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From page 39...
... However, the current system is designed to incentivize novelty through the publication of papers in scientific journals, and that does not necessarily translate to social benefit, such as improved treatments for patients. The replication of results has value, and, in fact, the scientific method relies upon it, but "the incentives just aren't aligned" to do this sort of work, said Geschwind.
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From page 40...
... (Duyk) •  ew business models built on global networking, investments in disease pre N vention diagnostics, and continued technological development will have a trans formative effect on translational medicine and cost-effectiveness.
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From page 41...
... Catalyzing Change Through Funding, Collaboration, and Goal Setting As a first step to improve the translation of basic science, Geschwind suggested that if funding agencies, such as the National Institutes of Health (NIH) , were to demand data sharing or collaborative multidisciplinary research, behaviors would change.
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From page 42...
... Regulatory agencies could also encourage data sharing. Rutter called attention to a recent report of the President's Council of Advisors on S ­ cience and Technology that recommended accelerated approval for some therapeutics, thereby allowing patients and physicians to decide if they would like to take greater risks (PCAST, 2012)
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From page 43...
... The distribution of funding over a broad range of recipients will not necessarily allow for the creation of an effective research model that people will follow, Duyk suggested. Similarly, a grand challenges approach can attract talent to problems that need to be solved, especially if this approach outlines a clear problem that needs to be solved and a prize is awarded as an incentive.
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From page 44...
... QB3 is a joint project between the University of California, San Francisco, the University of California, Berkeley, and the University of California, Santa Cruz, which merged the efforts of the faculties of the three universities. The faculty network brings expertise in a range of disciplines and a central facility provides services in support of bioscience entrepreneurs.
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Key Terms

  • data sharing
  • translational research
  • pharmaceutical companies
  • accelerated approval
  • academic promotion

  • effective translation
  • geschwind noted
  • encourage data
  • business models
  • final words

  • consider including
  • allowing patients
  • scientific journals
  • specific process
  • faculty network

  • promising researchers
  • genome project
  • markey fellowships
  • research piece
  • transfer issues

  • effective research
  • academic promotions
  • vention diagnostics
  • necessarily translate
  • thereby allowing

  • align tenure
  • achieving grand
  • disease community
  • duyk suggested
  • study recommended


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