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Frontiers of Engineering Reports on Leading-Edge Engineering from the 2014 Symposium (2015) / Chapter Skim
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Engineering Heart Valve Treatment Strategies for Tomorrow--W. David Merryman
Pages 65-70

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 65...
... Researchers are exploring a variety of alternatives: tissue engineering, percutaneous methods, and pharmacological intervention. HEART VALVES: PURE MECHANICS Heart valves are in many ways like the simple check valves in a household plumbing system or automobile engine; they are controlled by inertial fluid forces and ensure that flow is unidirectional.
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From page 66...
... Although this is an effective solution for many cases of valve disease, it is not a desirable option because the morbidity associated with an open-chest procedure is significant -- it is estimated that it takes up to a full year for a patient to return to previous levels of activity. As such, there have been concerted efforts to develop nonsurgical approaches for adult patients.
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From page 67...
... The mitral valve, unlike the aortic valve, is susceptible to a unique pathology called mitral valve prolapse in which the leaflets lose their ability to close properly and billow back into the atrium, causing regurgitant blood flow. Mitral valve prolapse is often treated with a percutaneous strategy called the Alfieri technique or "edge-to-edge" repair (George et al.
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From page 68...
... Arteriosclerosis, Thrombosis, and Vascular Biology 26:69–77. Engelmayr GC Jr, Rabkin E, Sutherland FW, Schoen FJ, Mayer JE Jr, Sacks MS.
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From page 69...
... Arteriosclerosis, Thrombosis, and Vascular Biology 33:114–120. Hutcheson JD, Aikawa E, Merryman WD.
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Key Terms

  • valve disease
  • aortic valve
  • mitral valve
  • heart valves
  • engineered heart

  • engineering heart
  • treatment strategies
  • endothelial cells
  • interstitial cells
  • valve interstitial

  • tissue engineering
  • valve tissue
  • degenerative valve
  • percutaneous mitral
  • calcific aortic

  • vascular endothelial
  • tissue engineered
  • blood vessels
  • adult patients
  • degenerative heart

  • human heart
  • native heart
  • valve leaflets
  • valve repair
  • valve endothelial

  • valve leaflet
  • valve tissues
  • caused heart
  • genital valve
  • valve mechanobiology


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