The Air Force Health Study Assets Research Program (2015) / Chapter Skim
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Appendix C: Abstracts of Approved Proposals
Appendix C: Abstracts of Approved Proposals
Pages 111-122
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From page 111... ...
(3) Relative to their lower-performing counterparts on tests of cognitive function, men with higher scores will have longer life expectancy, that is, a lower risk of all-cause mortality and major causes of death (such as cardiovascular disease and cancer)
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From page 112... ...
These novel results and the availability of unique biospecimens from the Air Force Health Study inspired us to collaborate on this effort to study the effects of dioxin exposure on DNA methylation marks in Vietnam veterans. Past studies have examined AFHS samples of adipose tissue, blood, and semen for their cellular and phenotypic attributes, but little molecular characterization has been performed using modern high-throughput techniques.
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From page 113... ...
, a hydrolase associated with the high density lipoprotein particle. PON1 has a lipolactonase activity that allows it to be protective of the cardiovascular system and its role in cardiovascular health is well documented.
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From page 114... ...
Principal Investigator: George Knafl, University of North Carolina at Chapel Hill Title: Effects of Dioxin Exposure for Male Air Force Vietnam Veterans on Reproductive Outcomes Assets Used: Electronic data only Abstract: The Air Force Health Study investigated the impact of herbicide exposure, especially to dioxin, on the health, survival, and reproductive outcomes of male Air Force veterans of the Vietnam War that were matched with a comparison group of Vietnam Air Force veterans not involved in those activities. Baseline data were collected in 1982.
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From page 115... ...
serum TCDD levels and less estrictive dose–response models r would provide a more precise, reliable and valid estimate of risk in the AFHS population. The second aim is to evaluate the impact of using sub-groups of the AFHS population and various comparison groups that differ from the comparisons defined in the original study protocol on the reliability and validity of the reported risks for cancer and diabetes associated with elevated serum TCDD levels.
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From page 116... ...
Principal Investigator: Adam Mitchell, Emory University and Atlanta VA Medical Center, Department of Veterans Affairs Title: Identifying Novel Biomarkers of Vulnerable Coronary Artery Disease: The Air Force Health Study Assets Used: Electronic data and biospecimens Abstract: Identification of patients at high risk for primary cardiovascular events (myocardial infarction and coronary death) and innovative prevention strategies could reduce the incidence of ischemic heart disease, a leading cause of morbidity and mortality.
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From page 117... ...
In addition, identification of microRNAs and metabolic derangements could uncover new signaling pathways that are important in the progression of athero clerosis s proximal to the development of adverse clinical outcomes. Principal Investigator: Kenneth Ramos, University of Louisville Title: Detection of L1 Protein in Ranch Hand Biospecimens Assets Used: Electronic data and biospecimens; pilot funding awarded Abstract: The Air Force Health Study is one of the most exhaustive epidemiologic investigations of adverse human health effects in Vietnam veterans possibly related to herbicide exposure during aerial application of herbicides.
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From page 118... ...
Measurement of L1ORF1p in serum may identify participants who have been diagnosed with cancer or those who are at increased risk of cancer development or malignant progression. Principal Investigator: Web Ross, Pacific Health Research and Education Institute, Department of Veterans Affairs Title: Parkinson's Disease and Premotor Features of Parkinson's Disease in the Air Force Health Study Assets Used: Electronic data only; pilot funding awarded Abstract: Evidence from epidemiologic and basic science research suggests pesticides contribute to Parkinson's disease risk.
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From page 119... ...
The role of caveolin and membrane lipid raft expression and serum cholesterol levels on the development of heart failure will be tested by investigating serum and adipose tissue samples from a pilot cohort of nonherbicide exposed participants: 15 participants that developed heart failure and 15 matched control participants who did not develop heart failure. Investigation will also include the role of serum cholesterol and tissue cholesterol levels on the development of heart failure by testing the total cholesterol content in whole serum and in a subset of whole adipose tissue samples.
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From page 120... ...
These tests will be used to attempt to determine if these participants have developed clinical features of amyloid disease by measuring known biomarkers of amyloid cardiomyopathy in the serum confirmed with adipose tissue as well as linking to mortality cause information suggests they may have died due to amyloidosis. Principal Investigator: Youn Shim, Centers for Disease Control and Prevention Title: Monoclonal Gammopathy of Undetermined Significance and MicroRNAs in Ranch Hand Veterans Assets Used: Electronic data and biospecimens; pilot funding awarded Abstract: Monoclonal gammopathy of undetermined significance (MGUS)
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From page 121... ...
For this purpose, we will use serum specimens stored at three time points (1982, 1992, and 2002)
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