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From page 161... ... , 1, 6 7, 9, 85-86, 103 Animal Welfare Standards, 114 Antibiotics, 73-74, 96-97 Anxiety, interspecies, 90 Association of Official Analytical Chemists, 62 AWRs, see Animal Welfare Regulations (AWRs) Axenic animals, 28-29, 62, 65, 124 Read the entire page →
From page 162... ... , 76 Circadian regulation, 57 Circular and circular-paired mating systems, 40 Cleaning of animal facilities, 66-69, 122 Climate-controlled passageways, 115 Closed-circuit television, 120 Coisogenic strains, 19, 23 Color-coding, 70-71 Common ancestral branch, 37 Compliance, 1, 3, 7, 9- 11, 71 Compromised-immune-status animals, 66, 69 Computer-controlled security systems, 120 Congenic strains, l9, 23 Containment facilities, 116 INDEX Continuing education, 11 Conventionally maintained animals, 29 "Core" agents monitored, 91 Cryopreservation, 37-38' 40-42, 151 D Defined-flora animals, 29 Degus (Octodon degas) , 128 Deprivation, 3, 8 Detergents, see Cleaning of animal facilities Diabetes mellitus, 142- 147 Diabetes-prone or diabetes-resistant strains, 140-147 Disease agents, see Infectious agents Disinfectants, 87; see also Cleaning of animal racllltles Distress, see Pain Drinking Water, see Water E Education, public, 4; see also Training programs Electrophoretic typing of isoenzymes, 31 ELISA (enzyme-linked immunosorbent assay) Read the entire page →
From page 163... ... , 139 Hazardous agents? 3, 13-15 designing facilities for handling, 119 in bedding, 67 in cell cultures, 15 in excrement, 14 in exhaust air, 53 in tissue samples, 15, 70, 89 in water, 70 viral replication of, 152 zoonotic diseases, 12, 128, 152 Health Research Extension Act, 1 Heteromyid rodents, 128 Hibernating animals, 74, 127, 139 Homogeneity of experimental animals, 31 Homologous recombination, 25-26 Humidity, 50-52, 125 Hybridization heterozygous, 39-40 residual, 21 segregating, 19 uniform, 18 homozygous, 19-20, 150 Hybrids, 18, 23 Hypothermia for neonate anesthesia, 102 Hysterectomy-derived animals, 86, 88 Hystricomorph rodents, 128 I Chinese (Cricetulus barabensis [griseus] Read the entire page →
From page 164... ... 127 INDEX International Rat Genetic Nomenclature Committee, 21 Interspecies anxiety, 90 Investigations involving animal use, 2, 6-7 involving disease outbreaks, 96 Isogeneity, 18-19 Isolating infected animals, 54 Isolator-maintained animals, 28, 47, 119, 123-124, 126, 148 K "Knockout" mutations, 25, 146 L Laboratory codes, 22-23 Laboratory recordkeeping, 12-13, 42, 71-72, 136, 150-151 Lactation, 143- 144 LCM, see Infectious agents, lymphocytic choriomeningitis (LCM) virus Life span, 130-132 Life tables for mouse strains, 132 Light intensity, 55-57, 135 M Macroenvironment, 50 MAP, see Testing, mouse antibodyproduction (MAP) Read the entire page →
From page 165... ... , 2 Outbred populations, 20, 27 p Pain, 3, 7, 10, 98-100, 102, 105 Parental strains, 21, 23, 36 Patent law, 152 165 Pathogen-free animals, 29 Pedigree management, 35-38, 41 Personnel allergies, 13 prophylactic immunization, 12-14, 128 qualifications, 8-11 records, 13 safety and health concerns, 12-14, 88 serum-banking for, 13-14, 152 tetanus shots for, 13, 128 training, 6, 9-11 Pest control, 70-71, 91 Pets, rodents as, 91 Phenotype preservation, 141-142 Pheromones, 67, 128 Photoperiod control, 55-56 PHS Policy, see Public Health Service Policy on Humane Care and Use of Laboratory Animals Pododermatitis, 45 Polygenic-trait analysis, 132, 146 Population dynamics, 47 Pregnancy, 143- 144 Presbycusis, 139 Preventative medicine. 85-90 Procurement, 85-87 Production colonies, 39 Protective wear, 13, 127 Protocol review, 7-9 Public accountability, 1 Public Health Service Policy on Humane Care and Use of Laboratory Animals, 1-2, 6-7, 9, 85, 106 Q Quarantine during disease outbreak, 96 of newly arrived animals, 54, 86-89, 91, 137 regulations, 40-41, 152 R Radioisotope use, 14-15 Randomization, structured, 39 Random-mated populations, 20 Rat Genome, 21 Rats black (Rattus rattus) Read the entire page →
From page 166... ... , 2 Regulatory issues, 1-3, 10 Reproductive performance, 36, 38-39 Resuscitation, 102- 103 "Ring tail," 51 Risk assessment, 12 Rodent pathogens, see Infectious agents Rodent pets, prohibiting, 91 Rodents in laboratory research advantages of, 17-18 quality considerations, 27-31 S Safety procedures, 13; see also Hazardous agents Sanitation, 45~6, 66-71 Security systems, 120 Sedation, see Pain alleviation Segregating inbred strains, 19, 23 Seizures, audiogenic, 58 Self-regulation by institutions, 2 Senescence-accelerated mice (SAM) , 132 Sentinel animals, 96-97, 126, 137, 148 virus-free, 89 Seroconversion, 96 Social requirements of rodents, 48 Sound-induced stress, 57-58 Space recommendations for animals, 47-49 for facility, 6, 116- 117 Species selection, 7, 16-32 Specific-pathogen-free (SPF) Read the entire page →
From page 167... ... See Hazardous agents Viruses, see Infectious agents Visitor control, 91 Vocalizations, 57 Voles (Microtus spp.) , 128 W Water, 46, 64-65, 125-126 Wild animals, 127-130 Woodchucks (Marmota monox) Read the entire page →

From page 161...

... , 1, 6 7, 9, 85-86, 103 Animal Welfare Standards, 114 Antibiotics, 73-74, 96-97 Anxiety, interspecies, 90 Association of Official Analytical Chemists, 62 AWRs, see Animal Welfare Regulations (AWRs) Axenic animals, 28-29, 62, 65, 124

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From page 162...

... , 76 Circadian regulation, 57 Circular and circular-paired mating systems, 40 Cleaning of animal facilities, 66-69, 122 Climate-controlled passageways, 115 Closed-circuit television, 120 Coisogenic strains, 19, 23 Color-coding, 70-71 Common ancestral branch, 37 Compliance, 1, 3, 7, 9- 11, 71 Compromised-immune-status animals, 66, 69 Computer-controlled security systems, 120 Congenic strains, l9, 23 Containment facilities, 116 INDEX Continuing education, 11 Conventionally maintained animals, 29 "Core" agents monitored, 91 Cryopreservation, 37-38' 40-42, 151 D Defined-flora animals, 29 Degus (Octodon degas) , 128 Deprivation, 3, 8 Detergents, see Cleaning of animal facilities Diabetes mellitus, 142- 147 Diabetes-prone or diabetes-resistant strains, 140-147 Disease agents, see Infectious agents Disinfectants, 87; see also Cleaning of animal racllltles Distress, see Pain Drinking Water, see Water E Education, public, 4; see also Training programs Electrophoretic typing of isoenzymes, 31 ELISA (enzyme-linked immunosorbent assay)

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From page 163...

... , 139 Hazardous agents? 3, 13-15 designing facilities for handling, 119 in bedding, 67 in cell cultures, 15 in excrement, 14 in exhaust air, 53 in tissue samples, 15, 70, 89 in water, 70 viral replication of, 152 zoonotic diseases, 12, 128, 152 Health Research Extension Act, 1 Heteromyid rodents, 128 Hibernating animals, 74, 127, 139 Homogeneity of experimental animals, 31 Homologous recombination, 25-26 Humidity, 50-52, 125 Hybridization heterozygous, 39-40 residual, 21 segregating, 19 uniform, 18 homozygous, 19-20, 150 Hybrids, 18, 23 Hypothermia for neonate anesthesia, 102 Hysterectomy-derived animals, 86, 88 Hystricomorph rodents, 128 I Chinese (Cricetulus barabensis [griseus]

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From page 164...

... 127 INDEX International Rat Genetic Nomenclature Committee, 21 Interspecies anxiety, 90 Investigations involving animal use, 2, 6-7 involving disease outbreaks, 96 Isogeneity, 18-19 Isolating infected animals, 54 Isolator-maintained animals, 28, 47, 119, 123-124, 126, 148 K "Knockout" mutations, 25, 146 L Laboratory codes, 22-23 Laboratory recordkeeping, 12-13, 42, 71-72, 136, 150-151 Lactation, 143- 144 LCM, see Infectious agents, lymphocytic choriomeningitis (LCM) virus Life span, 130-132 Life tables for mouse strains, 132 Light intensity, 55-57, 135 M Macroenvironment, 50 MAP, see Testing, mouse antibodyproduction (MAP)

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From page 165...

... , 2 Outbred populations, 20, 27 p Pain, 3, 7, 10, 98-100, 102, 105 Parental strains, 21, 23, 36 Patent law, 152 165 Pathogen-free animals, 29 Pedigree management, 35-38, 41 Personnel allergies, 13 prophylactic immunization, 12-14, 128 qualifications, 8-11 records, 13 safety and health concerns, 12-14, 88 serum-banking for, 13-14, 152 tetanus shots for, 13, 128 training, 6, 9-11 Pest control, 70-71, 91 Pets, rodents as, 91 Phenotype preservation, 141-142 Pheromones, 67, 128 Photoperiod control, 55-56 PHS Policy, see Public Health Service Policy on Humane Care and Use of Laboratory Animals Pododermatitis, 45 Polygenic-trait analysis, 132, 146 Population dynamics, 47 Pregnancy, 143- 144 Presbycusis, 139 Preventative medicine. 85-90 Procurement, 85-87 Production colonies, 39 Protective wear, 13, 127 Protocol review, 7-9 Public accountability, 1 Public Health Service Policy on Humane Care and Use of Laboratory Animals, 1-2, 6-7, 9, 85, 106 Q Quarantine during disease outbreak, 96 of newly arrived animals, 54, 86-89, 91, 137 regulations, 40-41, 152 R Radioisotope use, 14-15 Randomization, structured, 39 Random-mated populations, 20 Rat Genome, 21 Rats black (Rattus rattus)

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From page 166...

... , 2 Regulatory issues, 1-3, 10 Reproductive performance, 36, 38-39 Resuscitation, 102- 103 "Ring tail," 51 Risk assessment, 12 Rodent pathogens, see Infectious agents Rodent pets, prohibiting, 91 Rodents in laboratory research advantages of, 17-18 quality considerations, 27-31 S Safety procedures, 13; see also Hazardous agents Sanitation, 45~6, 66-71 Security systems, 120 Sedation, see Pain alleviation Segregating inbred strains, 19, 23 Seizures, audiogenic, 58 Self-regulation by institutions, 2 Senescence-accelerated mice (SAM) , 132 Sentinel animals, 96-97, 126, 137, 148 virus-free, 89 Seroconversion, 96 Social requirements of rodents, 48 Sound-induced stress, 57-58 Space recommendations for animals, 47-49 for facility, 6, 116- 117 Species selection, 7, 16-32 Specific-pathogen-free (SPF)

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From page 167...

... See Hazardous agents Viruses, see Infectious agents Visitor control, 91 Vocalizations, 57 Voles (Microtus spp.) , 128 W Water, 46, 64-65, 125-126 Wild animals, 127-130 Woodchucks (Marmota monox)

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INDEX Pages 161-167

INDEX
Pages 161-167