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Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense (2015) / Chapter Skim
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1 Introduction
Pages 9-12

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From page 9...
... A collaboration that has been informally referred to as Tox21 was formed between the National Toxicology Program of the National Institute of Environmental Health Sciences, the National Center for Computational Toxicology of the US Environmental Protection Agency (EPA) , and the Chemical Genomics Center1 of the National Institutes of Health; the US Food and Drug Administration joined the collaboration later.
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From page 10...
... If not, is there research that would enable DOD to use predictive-toxicology approaches to identify acute chemical threats? THE COMMITTEE AND ITS TASK The committee that was convened as a result of DOD's request included experts in toxicology, computational methods, high-throughput approaches, –omics, physiologically based pharmacokinetic modeling, statistics, model validation, and emergency preparedness (see Appendix A for the committee's biographical information)
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From page 11...
... In response to its task to "predict acute toxicity at levels relevant to DOD concerns," the committee focused its approach on hazard identification, specifically identifying target organ systems and developing toxicity estimates, such as potency estimates. An approach for predicting acute toxicity that involved converting toxicity estimates to human exposure estimates, as has been taken with some chemical-warfare agents (Mioduszewski et al.
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From page 12...
... Chapter 6 presents important lessons learned from previous predictive acute-toxicity efforts and the committee's overall conclusions. The committee also identifies several steps that DOD could begin to take toward developing highthroughput assays and computational approaches to identify chemicals that have the potential to induce life-threatening acute toxicity in deployed personnel.
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