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An Assessment of the NIH Women's Health Initiative (1993) / Chapter Skim
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Observational Study
Pages 77-80

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From page 77...
... It is anticipated that 45 clinical centers watt enroll approximately 100,000 women in the OS, following them for an average of nine years. Data collected at baseline are to be related to subsequent clinical events in order to examine the associations of both putative risk factors and protective factors with subsequent disease occurrence.
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From page 78...
... Despite, the OS participants having been drawn from a "convenience" sample, not a population-based sample, the OS population will be useful for examining associations between possible risk factors and disease; there is no a priori reason to believe that associations between possible risk factors and diseases will be different in this subgroup. In addition to the information obtained by questionnaires, a fasting blood draw (and in some cases a urine collection)
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From page 79...
... Bone densitomet~y studies and urine samples wait be collected from the OS participants at the three osteoporosis substudy centers every three years. The Clinical Coordinating Center estimates the cost of the first year follow-up by mail and the year three folIow-up visit to be $~.5 million.
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From page 80...
... . It is unclear whether the lack of such material reflects the prudent concentration of NTH staff on the CT when collecting material for the committee or a true lack of recent attention to the additional hypotheses being tested.
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Key Terms

  • additional hypotheses
  • clinical center
  • prospective cohort
  • supplemental questionnaire
  • clinical coordinating

  • cohort study
  • baseline information
  • coordinating center
  • putative risk
  • minority women

  • physiologic changes
  • pursue hypotheses
  • strongly recommends
  • questionnaire categories
  • prudent concentration

  • protective factors
  • supplementation hypotheses
  • error correction
  • women aged
  • little information

  • hypotheses related
  • participant characteristics
  • procedures notes
  • recruit minority
  • observational study

  • methods applied
  • family history
  • myriad relationships
  • fasting blood
  • osteoporosis substudy


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