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Appendix F: Update on the Status of Biological Processes
Pages 176-180

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From page 176...
... treatment of extracted energetic matenals. Direct biological detoxification of chemical agents may be based on specific enzymatic processes that would be implemented either as punned enzymes, nonviable whole-cell extracts, immobilized cells, or growing cell systems.
From page 177...
... lack of demonstration of proof of principle for practical process and reactor designs based on the reported enzyme systems. However, recent entwine charactenzation and laboratory development of treatment processes based on specific enzyme systems have been initiated and several positive results reported.
From page 178...
... . Vanous opd + transformants displayed differing levels of enzymatic active , and Western blot analysis of mycelial extracts from transformants confirmed the expression of a mature processed form (lacking the membrane targeting signal)
From page 179...
... BIOLOGICAL TREATMENT FOLLOWING NEUI~ALIZATION Mustard Chemical hydrolysis of mustard under alkaline conditions results in the formation of thiodiglyco} as the primary reaction product and numerous other tentatively identified dechlorinated reaction products. Biological treatment of the reaction products from mustard hydrolysis was indicated In the Altemadves report as one of the more promising applications of biological processes to the agent stockpile.
From page 180...
... BIOLOGICAL I~EATMENI FOLLOliVING WET AIR OXIDATION Application of wet air oxidation as a primary treatment process for chemical agents would result in the formation of aqueous solutions containing acetic acid and other low molecular weight organic compounds. Biological treatment of waste streams similar to those anticipated from wet air oxidation has been applied broadly at full scale.


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