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Acute Exposure Guideline Levels for Selected Airborne Chemicals Volume 20 (2016) / Chapter Skim
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Appendix B Benchmark Concentration Calculations for Selected Chloroformates
Pages 135-142

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From page 135...
... is the cumulative normal distribution function Dependent variable = Mean Independent variable = Dose Slope parameter is not restricted Total number of observations = 4 Total number of records with missing values = 0 Maximum number of iterations = 250 Relative Function Convergence has been set to: 1e-008 Parameter Convergence has been set to: 1e-008 User has chosen the log transformed model Default Initial (and Specified) Parameter Values Background = 0 Intercept = -20.4973 Slope = 5.16963 Asymptotic Correlation Matrix of Parameter Estimates Intercept Intercept 1 *
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From page 136...
... Benchmmark Dose Com mputation Specifiied effect = 0.0 05 Risk Ty ype = Extra rissk Confid dence level = 0..95 BMD = 49.6524 BMDL L = 42.4113 FIGUR RE B-1 Prohibit model m with 0.95 5 confidence leveel.
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From page 137...
... is the cumulative normal distribution function Dependent variable = Mean Independent variable = Dose Slope parameter is not restricted Total number of observations = 6 Total number of records with missing values = 0 Maximum number of iterations = 250 Relative Function Convergence has been set to: 1e-008 Parameter Convergence has been set to: 1e-008 User has chosen the log transformed model Default Initial (and Specified) Parameter Values Background = 0 Intercept = -7.2918 Slope = 1.72308 Asymptotic Correlation Matrix of Parameter Estimates Intercept Slope Intercept 1 -1 Slope -1 1 *
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From page 138...
... C iss the cumulativ ve normal distrribution functioon
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From page 139...
... Analysis of Deviance Table Model Log (likelihood) Deviance Test DF P-value Full model 17.6143 – – – Fitted model 18.0291 0.829451 6 0.9913 Reduced model 47.9918 60.755 7 <0.0001 AIC: 40.0581.
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From page 140...
... C iss the cumulativ ve normal distrribution functioon
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From page 141...
... Deviance Test DF P-value Full model 12.8388 – – – Fitted model 14.2231 2.76871 2 0.2505 Reduced model 27.6759 29.6742 3 <0.0001 AIC: 32.4462. Goodness of Fit Scaled Dose Estimated Probability Expected Observed Size Residual 22.8000 0.0659 0.659 0 10 0.8398 26.6000 0.2559 2.559 4 10 1.044 34.3000 0.7728 7.728 7 10 -0.5491 46.9000 0.9934 9.934 10 10 0.2587 Chi-square = 2.16; DF = 2; P-value = 0.3390.
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From page 142...
... 142 Accute Exposure Guideline Levvels Benchmmark Dose Com mputation Specifiied effect = 0.0 05 Risk Ty ype = Extra rissk Confid dence level = 0..95 BMD = 22.2386 BMDL L = 18.0971 FIGUR RE B-4 Prohibit model m with 0.95 5 confidence leveel.
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Key Terms

  • parameter estimates
  • parameter values
  • values background
  • table model
  • deviance table

  • default initial
  • deviance test
  • parameter convergence
  • relative function
  • estimates variable

  • bound implied
  • error background
  • missing values
  • estimated probability
  • inequality constraint

  • function convergence
  • fit scaleed
  • scaleed dose
  • probability expected
  • correlation matrix

  • dependent variable
  • scaled dose
  • independent variable
  • fit scaled
  • dose com

  • benchmmark dose
  • slope parameter
  • dose slope
  • extra rissk
  • com mputation


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