Acute Exposure Guideline Levels for Selected Airborne Chemicals Volume 20 (2016) / Chapter Skim
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Appendix C Derivation of AEGL Values for Selected Chloroformates
Appendix C Derivation of AEGL Values for Selected Chloroformates
Pages 143-159
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From page 143... ...
In the absence of relevant data, AEGL-2 values were estimated by dividing the AEGL-3 values for methyl chloroformate by 3. Calculations: 10-min AEGL-2: 12 ppm ÷ 3 = 4.0 ppm 30-min AEGL-2: 8.5 ppm ÷ 3 = 2.8 ppm 1-h AEGL-2: 6.7 ppm ÷ 3 = 2.2 ppm 4-h AEGL-2: 4.2 ppm ÷ 3 = 1.4 ppm 8-h AEGL-2: 2.1 ppm ÷ 3 = 0.70 ppm Derivation of AEGL-3 Values for Methyl Chloroformate Key study: Hoechst.
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From page 144... ...
3 × 4 h = 304,900 ppm-h (42.4 ppm) 1 × 4 h = 170 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: C3 × 0.167 h = 304,900 ppm-h C3 = 1,825,748 ppm C = 122 ppm 122 ppm ÷ 10 = 12 ppm 30-min AEGL-3: C3 × 0.5 h = 304,900 ppm-h C3 = 609,800 ppm C = 84.8 ppm 84.8 ppm ÷ 10 = 8.5 ppm 1-h AEGL-3: C3 × 1 h = 304,900 ppm-h C3 = 304,900 ppm C = 67.3 ppm 67.3 ppm ÷ 10 = 6.7 ppm 4-h AEGL-3: 42.4 ppm ÷ 10 = 4.2 ppm 8-h AEGL-3: C1 × 8 h = 170 ppm-h C1 = 21.2 ppm C = 21.2 ppm 21 ppm ÷ 10 = 2.1 ppm Ethyl Chloroformate Derivation of AEGL-1 Values for Ethyl Chloroformate Insufficient data were available on ethyl chloroformate to derive AEGL-1 values, so no values are recommended.
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From page 145... ...
3 × 1 h = 112,769 ppm-h (48.3 ppm) 1 × 1 h = 48.3 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors
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From page 146... ...
In the absence of relevant data, AEGL-2 values were estimated by dividing the AEGL-3 values for isopropyl chloroformate by 3. Calculations: 10-min AEGL-2: 11 ppm ÷ 3 = 3.7 ppm 30-min AEGL-2: 11 ppm ÷ 3 = 3.7 ppm 1-h AEGL-2: 9.1 ppm ÷ 3 = 3.0 ppm
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From page 147... ...
3 × 6 h = 750,000 ppm-h (50 ppm) 1 × 6 h = 300 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: 11 ppm (set equal to 30-min AEGL-3 value, because of the uncertainty associated with extrapolating a 6-h point-of-departure to a 10-min value)
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From page 148... ...
Calculations: 10-min AEGL-2: 3.7 ppm 30-min AEGL-2: 3.7 ppm 1-h AEGL-2: 3.0 ppm 4-h AEGL-2: 1.9 ppm 8-h AEGL-2: 1.3 ppm Derivation of AEGL-3 Values for n-Propyl Chloroformate AEGL-3 values for n-propyl chloroformate were set equal to AEGL-3 values for isopropyl chloroformate, because of the inadequate data on n-propyl chloroformate and the similar toxicity of the two chemicals.
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From page 149... ...
In the absence of relevant data, AEGL-2 values were estimated by dividing the AEGL-3 values for allyl chloroformate by 3. Calculations: 10-min AEGL-2: 3.8 ppm ÷ 3 = 1.3 ppm 30-min AEGL-2: 2.6 ppm ÷ 3 = 0.87 ppm 1-h AEGL-2: 2.1 ppm ÷ 3 = 0.70 ppm 4-h AEGL-2: 0.53 ppm ÷ 3 = 0.18 ppm 8-h AEGL-2: 0.26 ppm ÷ 3 = 0.09 ppm Derivation of AEGL-3 Values for Allyl Chloroformate Key study: Stillmeadow Inc.
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From page 150... ...
3 × 1 h = 9,261 ppm-h (21 ppm) 1 × 1 h = 21 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: C3 × 0.167 h = 9,261 ppm-h C3 = 55,455 ppm C = 38 ppm 38 ppm ÷ 10 = 3.8 ppm 30-min AEGL-3: C3 × 0.5 h = 9,261 ppm-h C3 = 18,522 ppm C = 26.4 ppm 26.4 ppm ÷ 10 = 2.6 ppm 1-h AEGL-3: 21 ppm ÷ 10 = 2.1 ppm 4-h AEGL-3: C1 × 4 h = 21 ppm-h C1 = 5.25 ppm C = 5.25 ppm 5.25 ppm ÷ 10 = 0.53 ppm 8-h AEGL-3: C1 × 8 h = 21 ppm-h C1 = 2.63 ppm C = 2.63 ppm 2.63 ppm ÷ 10 = 0.26 ppm n-Butyl Chloroformate, Isobutyl Chloroformate, and sec-Butyl Chloroformate Data were insufficient to derive AEGL values for isobutyl or sec-butyl chloroformate.
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From page 151... ...
The values were also applied to isobutyl chloroformate and sec-butyl chloroformate. Calculations: 10-min AEGL-2: 12 ppm ÷ 3 = 4.0 ppm 30-min AEGL-2: 8.4 ppm ÷ 3 = 2.8 ppm 1-h AEGL-2: 6.7 ppm ÷ 3 = 2.2 ppm 4-h AEGL-2: 1.7 ppm ÷ 3 = 0.57 ppm 8-h AEGL-2: 0.83 ppm ÷ 3 = 0.28 ppm Derivation of AEGL-3 Values for n-Butyl Chloroformate Key study: BASF.
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From page 152... ...
3 × 1 h = 296,741 ppm-h (66.7 ppm) 1 × 1 h = 66.7 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: C3 × 0.167 h = 296,741 ppm-h C3 = 1,776,892 ppm C = 121 ppm 121 ppm ÷ 10 = 12 ppm 30-min AEGL-3: C3 × 0.5 h = 296,741 ppm-h C3 = 593,482 ppm C = 84.0 ppm 84.0 ppm ÷ 10 = 8.4 ppm 1-h AEGL-3: 66.7 ppm ÷ 10 = 6.7 ppm 4-h AEGL-3: C1 × 4 h = 66.7 ppm-h C1 = 16.8 ppm C = 16.8 ppm 16.8 ppm ÷ 10 = 1.7 ppm 8-h AEGL-3: C1 × 8 h = 66.7 ppm-h C1 = 8.34 ppm C = 8.34 ppm 8.34 ppm ÷ 10 = 0.83 ppm AEGL-3 values for n-butyl chloroformate were also applied to isobutyl chloroformate and sec-butyl chloroformate.
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From page 153... ...
3 × 4 h = 25,739 ppm-h (18.6 ppm) 1 × 4 h = 74.4 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors
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From page 154... ...
Derivation of AEGL-2 Values for Phenyl Chloroformate Insufficient data were available on phenyl chloroformate to derive AEGL-2 values. In the absence of relevant data, AEGL-2 values were estimated by dividing the AEGL-3 values for phenyl chloroformate by 3.
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From page 155... ...
3 × 4 h = 186.7 ppm-h (3.6 ppm) 1 × 4 h = 14.4 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: 0.72 ppm (set equal to 30-min AEGL-3 value, because of the uncertainty associated with extrapolating a 4-h point-of-departure to a 10-min value)
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From page 156... ...
In the absence of relevant data, AEGL-2 values were estimated by dividing the AEGL-3 values for 2-ethylhexyl chloroformate by 3. Calculations: 10-min AEGL-2: 3.6 ppm ÷ 3 = 1.2 ppm 30-min AEGL-2: 3.6 ppm ÷ 3 = 1.2 ppm 1-h AEGL-2: 2.9 ppm ÷ 3 = 0.97 ppm 4-h AEGL-2: 1.8 ppm ÷ 3 = 0.60 ppm 8-h AEGL-2: 0.91 ppm ÷ 3 = 0.30 ppm Derivation of AEGL-3 Values for 2-Ethylhexyl Chloroformate Key study: BASF.
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From page 157... ...
3 × 4 h = 23,719 ppm-h (18.1 ppm) 1 × 4 h = 72.4 ppm-h Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: 3.6 ppm (set equal to 30-min AEGL-3 value, because of the uncertainty associated with extrapolating a 4-h point-of-departure to a 10-min value)
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From page 158... ...
In the absence of relevant data, AEGL-2 values were estimated by dividing the AEGL-3 values for ethyl chlorothioformate by 3. Calculations: 10-min AEGL-2: 3.0 ppm ÷ 3 = 1.0 ppm 30-min AEGL-2: 3.0 ppm ÷ 3 = 1.0 ppm 1-h AEGL-2: 2.4 ppm ÷ 3 = 0.80 ppm 4-h AEGL-2: 1.5 ppm ÷ 3 = 0.50 ppm 8-h AEGL-2: 0.75 ppm ÷ 3 = 0.25 ppm Derivation of AEGL-3 Values for Ethyl Chlorothioformate Key study: Stauffer Chemical Company.
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From page 159... ...
Appendix C 159 Uncertainty factors: 3 for interspecies differences 3 for intraspecies variability Calculations: Point of departure ÷ product of the uncertainty factors 10-min AEGL-3: 3.0 ppm (set equal to 30-min AEGL-3 value, because of the uncertainty associated with extrapolating a 4-h point-of-departure to a 10-min value)
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