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Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders Proceedings of a Workshop (2017) / Chapter Skim
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Appendix A: References
Pages 61-66

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From page 61...
... 2015. Molecular mechanisms and animal models of spinal muscular atrophy.
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From page 62...
... 2012. Blinded prospective evaluation of computer-based mechanistic schizophrenia disease model for predicting drug response.
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From page 63...
... 2016. Genetic variability in a frozen batch of MCF-7 cells invisible in routine authentication affecting cell function.
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From page 64...
... 2016. A humanized clinically calibrated quantitative systems pharmacology model for hypokinetic motor symptoms in Parkinson's disease.
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From page 65...
... 2016. Mice with SHANK3 mutations associated with ASD and schizophrenia display both shared and distinct defects.
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Key Terms

  • animal models
  • drug discovery
  • clinical trials
  • stem cells
  • cns drugs

  • drug development
  • predicting drug
  • spinal cord
  • human molecular
  • blinded prospective

  • pharmacology model
  • scopolamine impairment
  • common neurobiological
  • cns drug
  • breakthrough cns

  • psychiatric disorders
  • tufts center
  • publication bias
  • recapitulates cardinal
  • fda approvals

  • motor symptoms
  • neurodegenerative diseases
  • der brug
  • drug response
  • affecting cell

  • pluripotent stem
  • pharmacology modeling
  • report volume
  • cell function
  • neurobiological substrate


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