Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine Proceedings of a Workshop (2018) / Chapter Skim
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Appendix C: Speaker Biographies
Appendix C: Speaker Biographies
Pages 108-124
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From page 108... ...
His research interests cover mouse functional genomics, including the use of mouse mutagenesis and comparative genomic analysis to study the genetic basis of disease and to develop pre-clinical disease models. A particular focus has been the use of mouse models to study the molecular basis of genetic deafness.
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From page 109... ...
For more than a decade, he has worked on the applications of human induced pluripotent stem cells disease modeling, specifically the pharmacogenomic and molecular mechanisms of chemotherapy-induced cardiomyopathy and heart failure.
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From page 110... ...
Ulrich Dirnagl's research focuses on stroke, cerebral blood flow regulation, and brain imaging. In preclinical models, as well as clinical trials, he and his
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From page 111... ...
, and how the brain interacts with other systems of the body after it has been injured. Closely linked to his interest in stroke pathophysiology is his interest in the coupling of regional blood flow to neuronal acitivity, the mechanism underlying functional brain imaging with magnetic resonance (MR)
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From page 112... ...
Her work focuses on cultural issues and international aspects of ethics in medicine, biomedical science, and public health; her research examines international standards of research ethics, education in the responsible conduct of research, and trainees' awareness of professional and cultural norms. She is co-director of the research ethics education program "Formação Colaborativa na Ética em Pesquisa (Collaborative Research Ethics Education)
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From page 113... ...
in Religious Studies in 1988 from Rice University's joint program in biomedical ethics with the University of Texas–Houston Health Science Center. Merel Ritskes Hoitinga is a professor in evidence-based laboratory animal science at the Department for Health Evidence at the Radboud University Medical Center, Nijmegen, the Netherlands.
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From page 114... ...
She served as the study director for six National Academies reports, including Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease (2011) , Determining Core Capabilities in Chemical and Biological Defense Science and Technology (2012)
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From page 115... ...
Kenjiro Kosaki received clinical and research training in medical genetics at the University of California, San Diego, and Baylor College of Medicine and received board certification in clinical genetics from the American Board of Medical Genetics. Currently, he is serving as the co-principal investigator for two government-funded national research projects of Japan in the field of medical genomics and rare diseases.
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From page 116... ...
He is currently chairing the International Committee on Taxonomy of Viruses Filoviridae and Mononegavirales Study Groups and is a subject-matter expert for the National Center for Biotechnology Information for all mononegaviruses; is a member of the editorial boards of Applied Biosafety -- Journal of the American Biological Safety Association, Archives of Virology, BioMed Research International, Journal of Bioterrorism and Biodefense, PLoS ONE, PLoS Pathogens, Viruses, Virologica Sinica, Voprosy Virusologii, and World Journal of Virology; was a member of the U.S. National Academy of Sciences' committee on animal models for assessing countermeasures to bioterrorism agents; and is continuously involved with the American Association for the Advancement of Science and the U.S.
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From page 117... ...
He was principal investigator of a number of National Institutes of Health (NIH) grants funded through the National Institute of Allergy and Infectious Diseases, National Institute of Aging, and National Institute of Diabetes and Digestive and Kidney Diseases and was a permanent member and chair of the NIH Comparative Medicine Review Committee.
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From page 118... ...
She continued as a postdoctoral researcher at the Wyss Institute for Biologically Inspired Engineering at Harvard University, where she engineered microscale human cardiac tissues on platforms with integrated functional assays, known as "heart-on-a-chip," for patient- specific disease modeling and medium-throughput drug screening.
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From page 119... ...
and master's degree in genetics from The George Washington University, and completed a postdoctoral research fellowship at the Children's National Medical Center. He was awarded the first American Society of Human Genetics/National Human Genome Research Institute Fellowship in Genetics and Public Policy, where he worked as a health legislative assistant in the House of Representatives.
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From page 120... ...
Alton Jones Cell Science Center, where he was executive director. He has served on a variety of national advisory committees, including the Health and Environmental Sciences Institute Board of Trustees, National Advisory General Medical Sciences at NIH, National Toxicology Program Board of Scientific Councilors, the Environmental Protection Agency Subcommittee on Chemical Safety for Sustainability, as well as the boards of directors for Argonex Pharmaceuticals and Upstate Biotechnology.
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From page 121... ...
Thayer was deputy division director of analysis at the National Toxicology Program (NTP) and director of the NTP Office of Health Assessment and Translation (OHAT)
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From page 122... ...
He served on the Board of Scientific Overseers of the Jackson Laboratory and the Advisory Council of the National Human Genome Research Institute. He has been a member of the editorial boards of The American Journal of Human Genetics, Human Molecular Genetics, Human Mutation, European Journal of Human Genetics, Annual Review of Nutrition, and Annual Review of Genomics and Human Genetics.
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From page 123... ...
His group's most recent innovations include the ongoing development of 96-channel microformulator, funded by AstraZeneca, and a smart well plate for organs-on-chips and high-throughput biology, funded by NCATS Small Business Innovation Research Program to CFD Research Corporation. VIIBRE is also the home of the Systems Biology and Bioengineering Undergraduate Research Experience, a year-round, multiyear program funded by Gideon Searle.
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