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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine Proceedings of a Workshop (2018) / Chapter Skim
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8 Reflections on the Workshop
Pages 87-89

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From page 87...
... Lloyd identified four persistent challenges for precision medicine research: • The growth in translational research has increased the incidence of exposing animal-based research that lacks reproducibility, which is not a good predictor of human response or disease. • There have been only modest gains in successful treatments; slow and expensive drug pipelines often end in failure in diverse patient populations.
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From page 88...
... As researchers continue to identify variants that are potentially relevant to human disease or health, we need to expand model organism resources and technology development for rapid assessment of variants, said Lloyd. These resources and technologies may include things like model-on-demand programs, expanded biorepositories and tissue/specimen banks, improved phenotypic validation, and steps to ensure predictive validity of models.
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From page 89...
... Through the eight sessions of the workshop, speakers identified specific challenges to the development of predictable, reproducible, and reliable animal models to support rapid and accurate identification and prioritization of causative factors of disease to support precision medicine research. Model organisms can improve precision medicine outcomes, provided that formal collaborations are established between researchers using animal models and precision medicine initiatives so that processes and projects such as comparative phenotyping, ontologies and functional annotation of the genome can move forward in tandem.
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Key Terms

  • animal models
  • model organisms
  • precision modeling
  • medicine initiatives
  • predictive value

  • integrate animal
  • identify knowledge
  • support rapid
  • researchers using
  • improved phenotypic

  • require work
  • specific human
  • researchers continue
  • functional annotation
  • expand availability

  • expanded biorepositories
  • phenotypic validation
  • regulatory regions
  • ensure predictive
  • computable phenotypes

  • medicine research
  • causative factors
  • speakers identified
  • predictive validity
  • apply comparative

  • rapid assessment
  • lloyd identified
  • accurate identification
  • human disease
  • patient data


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