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Advancing Disease Modeling in Animal-Based Research in Support of Precision Medicine Proceedings of a Workshop (2018) / Chapter Skim
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Appendix A: Agenda
Pages 95-102

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From page 95...
... According to the National Institutes of Health, precision medicine "is an approach for disease treatment and prevention that takes into account individual differences in lifestyle, environment, and biology."1 During the 1  See https://allofus.nih.gov/about/about-all-us-research-program.
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From page 96...
... The evolution and foundations of precision medicine  India Hook-Barnard, University of California, San Francisco The vision and goals of the All of Us Research Program  Petra Kaufmann, National Center for Advancing Translational Sciences The regulatory landscape of precision medicine  Robert M Califf, Duke University School of Medicine (remotely)
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From page 97...
... This session will explore the translatability, alignment, and relevance of current animal models to the human condition. Elements of precision in the design, creation, use, and data analysis of current animal models David Valle, Johns Hopkins University Comprehensive phenotyping of the mouse genome  Steve Brown, Medical Research Council, United Kingdom Functional analysis of genes essential for life  Mary Dickinson, Baylor College of Medicine Exploring genetic variability using precision pathology in animals Keith Mansfield, Novartis Lunch (Will be served for speakers, committee members 12:10pm  and Roundtable members in the Member's Room.
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From page 98...
... Improving diagnostics and therapeutics for Mendelian diseases using precision mouse models Robert Burgess, The Jackson Laboratory Co-clinical trials of mice and human patients  Sean Clohessy, Beth Israel Deaconess Medical J Center New Approaches to Disease Modeling Developing new "non-model" model systems Jennifer Maier, University of Illinois  Making connections between human and animal phenotypes  Melissa Haendel, Oregon Health & Science University The Animal Rule: A holistic approach to "precision"  Jens Kuhn, National Institutes of Health/National Institute of Allergy and Infectious Diseases Integrated Research Facility at Fort Detrick 3:20 Coffee Break
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From page 99...
... Subsequent presentations will examine ways with which reproducibility can be sustained in the context of precision modeling. The translational potential of animal models Ulrich Dirnagl, Charité, Berlin, Germany Systematic reviews, meta-analysis, and reproducibility  Merel Ritskes Hoitinga, Radboud University Medical Center, the Netherlands Biomedical computing, large databases, and reproducibility Arjun Kumar Manrai, Harvard Medical School Reproducibility in the alignment of the individual human patient and the "precise" animal model Jonathan Kimmelman, McGill University, Canada 5:15 Adjourn for the Day Friday, October 6 8:30am Precision Modeling In Vitro  Moderator: Brian Berridge, GlaxoSmithKline (Organizing Committee Co-Chair)
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From page 100...
... At the level of the individual patient, speakers will explore modeling and monitoring of drug safety; at the level of population health, the session will focus on population outcomes looking at the example of modeling environ mental exposures to potential intoxicants. How can data from animal models inform the transformation from healthcare that depends on population outcomes to one exploiting solely an individual's unique characteristics?
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From page 101...
... The United Kingdom's 100,000 Genomes Project  Damian Smedley, Genomics England, United Kingdom The French Plan for Genomic Medicine  Catherine Nguyen, ITMO Génétique, Génomique & Bioinformatique (GGB) , Paris, France Japan's Initiative on Rare and Undiagnosed Diseases  Kenjiro Kosaki, Keio University School of Medicine, Japan
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From page 102...
... Patient advocacy in the context of precision medicine Daryl Pritchard, Personalized Medicine Coalition Pets with naturally occurring tumors -- A natural model for improving cancer care and treatment Amy K LeBlanc, National Cancer Institute  Using precision medicine to help patients with Parkinson's Disease  Brian Fiske, The Michael J
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Key Terms

  • animal models
  • disease modeling
  • current animal
  • precision modeling
  • using precision

  • drug safety
  • ilar roundtable
  • organizing committee
  • oregon health
  • melissa haendel

  • human patient
  • precision mouse
  • precision animal
  • integrating precision
  • precision pathology

  • precision disease
  • diseases using
  • keio university
  • support human
  • jens kuhn

  • medicine initiative
  • improving human
  • beth israel
  • human clinical
  • animal modeling

  • account individual
  • clinical trials
  • translational potential
  • kumar manrai
  • sean clohessy


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