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Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood–Brain Barrier Proceedings of a Workshop (2018) / Chapter Skim
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5 Accelerating Research and Clinical Translation: Consortia and PublicPrivate Partnerships
Pages 31-40

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From page 31...
... . • Advancing innovative BBB research will require an increased fo cus on basic science, attracting more young researchers to the field, and supporting them to stay in the field (Brose, Gu, Lisanby, Talley, Thorne)
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From page 32...
... Ongoing projects in the United Stated and Europe provide lessons on what is needed to move the field forward and inform new funders who may provide novel approaches to catalyze research. Innovative Medicines Initiative The Innovative Medicines Initiative (IMI)
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From page 33...
... Initiative was launched in 2013 by President Barack Obama as a partnership of federal and nonfederal agencies and organizations focused on mapping all the circuits in the brain. Today the BRAIN Initiative includes foundations, independent research institutes, major research universities, and industry partners, and it has been supported by more than $150 million for research.2 Edmund Talley said that the BRAIN Initiative interfaces with strategies for crossing the BBB because of their relevance to issues of accessing and understanding circuity activity and modulating circuits.
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From page 34...
... was interested in repurposing existing devices for new indications, and was able to convince companies that it was in their interest to share preexisting safety data on their devices with investigators funded by the BRAIN Initiative, and to put information about their devices on the BRAIN Initiative website. They also set up a template research agreement for companies to use as a starting point for negotiations over intellectual property, said Talley.
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From page 35...
... A feature that sets CZI apart from other funders is its world-class technology engineering team. By assembling top engineers from areas outside of the scientific community who have experience managing and interpreting enormous quantities of disparate data, CZI hopes to leverage its expertise in partnership with scientists to advance the development of enabling tools and technologies that can drive innovation in biomedicine, said Brose.
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From page 36...
... For example, Campany recently ran a prize competition to develop a portable, wireless technology to monitor and diagnose health conditions and thus expand access to health care and better use limited health care resources. He said 300 teams from leading research institutions around the world vied for the prize, and after 4 years and extensive testing of prototypes, two teams were selected as winners, taking home several million dollars.
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From page 37...
... Both are needed, he said. However, Danica Stanimirovic suggested that it may be a fallacy to divide basic science, applied science, and drug delivery into silos rather than thinking of them along a continuum.
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From page 38...
... Thorne agreed that while the field is small, it is truly multidisciplinary, comprising physicists, modelers, immunologists, cell biologists, and neuroscientists, while straddling basic and applied science. The nature of this multidisciplinary science surrounding the central nervous system (CNS)
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From page 39...
... He supported international cooperative efforts as an alternative. Andrew Welchman elaborated on international collaborative awards, noting that teams funded by Wellcome bring together purely academic teams or teams of both academic and industry scientists.
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From page 40...
... William Potter suggested that advancing understanding of the BBB could be achieved through a systematic evaluation and prioritization of tools. For example, he suggested that the technology already exists with positron emission topography imaging and radiolabeled ligands to quantify a biologic agent as it enters the brain, yet these tools are not being used for this purpose.
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Key Terms

  • accessed january
  • medicines initiative
  • innovative medicines
  • bbb research
  • advancing research

  • research space
  • wellcome supports
  • zuckerberg initiative
  • advancing innovative
  • chan zuckerberg

  • applied science
  • industry partners
  • thorne suggested
  • drug development
  • sarah lisanby

  • andrew welchman
  • brain barrier
  • international brain
  • brain research
  • bbb science

  • collaborative awards
  • clinical science
  • includes foundations
  • human cell
  • multiple disease

  • workshop ranged
  • particularly adept
  • existing devices
  • cns barriers
  • drug discovery


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