Enabling Novel Treatments for Nervous System Disorders by Improving Methods for Traversing the Blood–Brain Barrier Proceedings of a Workshop (2018) / Chapter Skim
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1 Introduction and Overview
1 Introduction and Overview
Pages 1-4
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The BBB has been historically viewed simply as a physical barrier, according to Danica Stanimirovic, director of the Translational Bioscience Department at the National Research Council of Canada. Yet we now know that it is a complex dynamic system that involves multiple cell types and transporters and interacts with other elements in its environment, she said.
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BOX 1-1 Statement of Task An ad hoc committee will plan and conduct a 1-day public workshop that will bring together key stakeholders from government, academia, industry, and disease-focused organizations to explore the current devel opment of novel methods for traversing the blood–brain barrier to deliver therapeutics for nervous system disorders and identify potential opportunities for moving the field forward. • Provide an overview of current knowledge on the role of the blood–brain barrier biology and delivery mechanisms, examining gaps in our current knowledge that future research may address.
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Chapter 4 explores regulatory issues and concerns for investigators to consider as they move through preclinical and clinical phases of development. Chapter 5 examines innovative funding models and partnership strategies to accelerate research and facilitate clinical translation of these technologies by increasing collaboration and establishing PPPs across various stakeholder communities, including academia, industry, the private sector, and federal agencies.
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