Feasibility of Addressing Environmental Exposure Questions Using Department of Defense Biorepositories Proceedings of a Workshop–in Brief (2018) / Chapter Skim
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Feasibility of Addressing Environmental Exposure Questions Using Department of Defense Biorepositories: Proceedings of a Workshop - in Brief
Feasibility of Addressing Environmental Exposure Questions Using Department of Defense Biorepositories: Proceedings of a Workshop - in Brief
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Murtha Cancer Center, provided an overview of the Murtha Cancer Center repository.
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"Through these collaborations with academia and internal DoD, Murtha Cancer Center samples contribute to about 100 peer-reviewed publications a year, in very high impact journals." A few studies have used tissue specimens to examine environmental exposures, such as polychlorinated biphenyls and pesticides in breast tissue. The Murtha Cancer Center also collects information 2
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He made this point by presenting epidemiological analyses of C8 Science Panel Study data that used different exposure measurements. In an analysis that retrospectively associated the serum PFOA measurements from 2005 to 2006 with preeclampsia in pregnancies, the risk estimates were weak for exposures above the median (adjusted odds ratio: 1.1 per interquartile range [IQR]
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These approaches can be applied to less invasive biological sampling techniques, such as dried blood spots. Non-targeted Analysis of Archived Specimens for Discovering Past Exposures Dr.
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Non-targeted analysis methods are certainly tools that can inform a retrospective exposure assessment but great care must be taken to avoid misinterpretation of data that are meant for discovery more than routine monitoring. Challenges and Opportunities in Developing a Search Engine for Exposures Associated with Disease Risk Dr.
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Deployment-associated Exposure Surveillance with High-Resolution Metabolomics Opening the next half of the session, Dr. Dean Jones of Emory University also discussed the utility of non-targeted metabolomic exposure monitoring technology and the application of that technology to observing differences in patterns of exposures associated with deployment.
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According to Walker, the exposome wide association studies and metabolome wide association profiling of DoD serum repository samples could be integrated into current protocols, which could greatly improve DoD's chemical surveillance and monitoring of early biological effects (Walker et al.
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Improvements in the quality and availability of highly sensitive analytic instrumentation, such as liquid chromatography tandem mass spectrometry (LC-MS/MS) , as well as new methodological approaches for collection and storage, and improvements in measurement interpretation are factors driving the increasing interest in dried blood spots.
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Some scenarios where pooling might be useful to DoD include, an initial test of hypotheses regarding potential exposures associated with deployment or occupation, suspect chemical screening or non-targeted analysis, initial hypothesis tests of diseaseexposure associations, and to validate or refine external exposure indices. In a study of 150 airport firefighters who trained extensively with firefighting foam, that contains perfluorinated compounds, Aylward and her colleagues analyzed individual samples for perfluorinated compounds.
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2017. "State of the Science in Dried Blood Spots." Clinical Chemistry (2017)
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Reviewers: To ensure that it meets institutional standards for quality and objectivity, this Proceedings of a Workshop -- in Brief was reviewed by Lesa Aylward, Summit Toxicology; Marike Kolossa-Gehring, German Environment Agency; Megan Latshaw, Johns Hopkins University; and Hyeong Moo Shin, University of Texas at Arlington. Planning Committee for Feasibility of Addressing Environmental Exposure Questions Using Department of Defense Biorepositories: A Workshop: Joyce Tsuji (Chair)
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