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Transgenic Neuroscience Research Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop (2019) / Chapter Skim
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Appendix B: Workshop Agenda
Pages 61-68

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From page 61...
... While no animal model will fully recapitulate human nervous system disorders, nonhuman primates (NHPs) -- such as marmosets and macaques -- have shown promise in their ability to serve as models for complex brain disorders, given the phylogenetic proximity and genetic similarity to humans, similarity of neuroanatomical organization (e.g., a well-developed prefrontal cortex)
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From page 62...
... and explore how they would need to be modified for use in other animal models, such as nonhuman primates. • Consider bioethical principles and issues related to genetic engineering of animal models for nervous system disorders, and discuss potential metrics for determining the models' readiness for nonhuman primate research.
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From page 63...
... 8:55 a.m. Speakers GUOPING FENG, Massachusetts Institute of Technology HIDEYUKI OKANO, Keio University School of Medicine; RIKEN Brain Science Institute YOLAND SMITH, Yerkes National Primate Research Center; Emory University ANGELA ROBERTS, University of Cambridge 9:55 a.m.
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From page 64...
... 11:00 a.m. Speakers MU-MING POO, Chinese Academy of Sciences BEN DEVERMAN, Broad Institute of Massachusetts Insti tute of Technology and Harvard University JEAN BENNETT, University of Pennsylvania KAREN PARKER, Stanford University 12:00 p.m.
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From page 65...
... - What criteria must be met in order to justify the use of nonhuman primates in transgenic and chimeric neurosci ence research, that is, type and importance of research questions; unique aspects of nonhuman primates; data from other research models; clinical testing that cannot be performed in human subjects, etc.? - What are the possibilities that transgenic and chimeric neuroscience research in NHPs could confer some quali tatively different aspect of cognition on the NHP?
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From page 66...
... Panel Discussion JOHN MORRISON, California National Primate Research Center, University of California, Davis HIDEYUKI OKANO, Keio University School of Medicine; RIKEN Brain Science Institute JOSHUA GORDON, National Institute of Mental Health MARK FRASIER, The Michael J Fox Foundation for Parkinson's Research
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From page 67...
... Closing Remarks STEVEN HYMAN, Broad Institute of Massachusetts Institute of Technology and Harvard University 5:30 p.m. Adjourn Workshop
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Key Terms

  • neuroscience research
  • primate models
  • nonhuman primates
  • primate research
  • chimeric nonhuman

  • animal models
  • national primate
  • chimeric neuroscience
  • discuss potential
  • advance research

  • bioethical principles
  • discuss policies
  • brain disorders
  • keio university
  • emerging transgenic

  • science institute
  • social cognition
  • prefrontal cortex
  • yoland smith
  • eye institute

  • tomical organization
  • potential development
  • yerkes national
  • shown promise
  • genetic similarity

  • recapitulate human
  • chimeric technologies
  • consider bioethical
  • primate center
  • broad institute


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