Skip to main content

Transgenic Neuroscience Research Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models: Proceedings of a Workshop (2019) / Chapter Skim
Currently Skimming:

2 Genetically Modified Nonhuman Primate Models for Neuroscience Research: Rationale and Overview of Potential Opportunities and Challenges
Pages 7-14

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 7...
... , Alzheimer's disease, amyotrophic lateral sclerosis, stroke, and autism, said Hideyuki Okano, dean of the Keio University Graduate School of Medicine and team leader of the Laboratory for Marmoset Neural Architecture at the RIKEN Center for Brain Science. These models and others in nonhuman primates may also facilitate the development of novel and personalized treatments for neuropsychiatric disorders, said Angela Roberts, professor of behavioral neuroscience at the University of Cambridge.
Read the entire page →
From page 8...
... rodent cortex results in a limited repertoire of cognitive function and this makes it difficult to interpret cognitive changes in a way that is translatable to humans, said Yoland Smith, professor of neurology and director of the neuropharmacology and neurological diseases division at the Yerkes National Primate Center of Emory University. The small size of the rodent brain also makes it difficult to translate new therapies from the bench to people, said Smith.
Read the entire page →
From page 9...
... SOURCES: Presented by Guoping Feng, October 4, 2018; adapted from Kaiser and Feng, 2015. OPPORTUNITIES PROVIDED BY NONHUMAN PRIMATE MODELS TO FOSTER NEUROSCIENCE RESEARCH Nonhuman primate models enable enhanced understanding of behavior and higher cortical function, potentially better model neurodegenerative and neuropsychiatric disorders, and can be used to advance therapeutic development, including developing personalized treatments, testing drugs for safety before their first use in humans, and facilitating biomarker discovery.
Read the entire page →
From page 10...
... His team is also generating opsin knock-in monkeys, which will open the door to optogenetic approaches that have proved so valuable in increasing understanding of neural connectivity and circuit function. CHALLENGES OF GENETICALLY MODIFIED NONHUMAN PRIMATE MODELS While there are a number of opportunities afforded by the use of genetically modified nonhuman primate models for neuroscience research, challenges remain related to logistics and feasibility, selecting the appropriate primate species to study a specific disorder or disease, developing tools to bridge translation findings from nonhuman primates to humans, and exploring ethical considerations.
Read the entire page →
From page 11...
... Nonseasonal breeders allow scientists to generate genetically modified animal models year-round through assisted reproductive technology. Homozygous animals, while desirable for many types of studies aimed at understanding gene function, can take a long time to breed.
Read the entire page →
From page 12...
... a behavior first approach using models with face validity in that they exhibit naturally occurring social deficits; (2) a genetics first approach with construct validity that uses homologous pathogenic variants, selective breeding, and/or genome engineering; and (3)
Read the entire page →
From page 13...
... Exploring Ethical Considerations The justification for using genetically modified nonhuman primate models comes down to the limitations of doing certain kinds of research in humans or in other research models, said Jeffrey Kahn, the Andreas C Dracopoulos director of the Johns Hopkins Berman Institute of Bioethics.
Read the entire page →
From page 14...
... 14 TRANSGENIC NEUROSCIENCE RESEARCH this "valuable and valued resource." Then, if research on nonhuman primates is determined to be justified, oversight by people with specialized expertise is needed, said Kahn. Ethical issues related to the use of nonhuman primate models are further explored in Chapter 5.
Read the entire page →

Key Terms

  • primate models
  • modified nonhuman
  • nonhuman primates
  • neuroscience research
  • genetically modified

  • animal models
  • life span
  • genome editing
  • human clinical
  • rodent models

  • clinical trials
  • rhesus monkeys
  • candidate signaling
  • enable scientists
  • personalized treatments

  • neuropsychiatric disorders
  • construct validity
  • national primate
  • primate behavioral
  • research nonhuman

  • priate primate
  • primate center
  • primate species
  • animal research
  • shorter life

  • human diseases
  • models enable
  • using genetically
  • developing personalized
  • fied animal


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.