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A Class Approach to Hazard Assessment of Organohalogen Flame Retardants (2019) / Chapter Skim
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Appendix C: Methodologic Details of Literature Surveys and Searches
Pages 63-74

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From page 63...
... The case ex- sidered untested in database; otherwise, it is tested amples described in Chapter 3 built on this initial survey in database. of data availability by including additional published data • ToxNet.
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From page 64...
... The sidebar colors indicate chemotype classes. Figure available at www.nap.edu/25412.
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From page 65...
... Each group (chemotype class) is plotted according to the frequency of chemicals in that class on which data are available.
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From page 66...
... are available. The sidebar colors indicate chemotype classes.
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From page 67...
... The from the list of 161 chemicals in the OFR inven- searches used the following terms: tory. Activity data on 40 chemicals with acceptable analytic chemistry data or those still under analytic Chemical-specific terms for polyhalogenated bisphenol analysis were available for 43 toxicity end points.
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From page 68...
... @tox21−fxr−bla−agonist−p2 increase activity of ratandrogen receptor transcriptional factor (sex hormone homeostasis) @tox21−ar−bla−agonist−p1 decrease activity of human peroxisome proliferator activated receptor delta transcriptional factor (lipid homeostasis)
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From page 69...
... ethane DBE−DBCH or TBECH TDBPP FIGURE C-5 Heatmap that represents availability of ToxCast data on the chemicals in the OFR inventory. Figure available at www.nap.
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From page 70...
... Polyhalogenated bisphenol aliphatics "66710-97-2"[CompleteSynonym] 0 "55205-38-4"[CompleteSynonym]
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From page 71...
... Polyhalogenated bisphenol aliphatics: Search Terms 1 "Tetrabromobisphenol A bis(2-hydroxyethyl) ether bis(acrylate)
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From page 72...
... Polyhalogenated bisphenol aliphatics: Searches 15 #1 AND #12 20 16 #1 AND #13 0 17 #1 AND #14 7 18 #2 AND #12 0 19 #2 AND #13 0 20 #2 AND #14 0 21 #3 AND #12 2 22 #3 AND #13 0 23 #3 AND #14 0 24 #4 AND #12 0 25 #4 AND #13 0 26 #4 AND #14 0 27 #5 AND #12 0 28 #5 AND #13 0 29 #5 AND #14 1 30 #6 AND #12 0 31 #6 AND #13 0 32 #6 AND #14 0 33 #7 AND #12 291 34 #7 AND #13 4 35 #7 AND #14 40 36 #8 AND #12 1 37 #8 AND #13 0 38 #8 AND #14 0 39 #9 AND #12 6 40 #9 AND #13 0 41 #9 AND #14 1 42 #10 AND #12 2 43 #10 AND #13 0 44 #10 AND #14 1 45 #11 AND #12 25 46 #11 AND #13 0 47 #11 AND #14 5 Polyhalogenated organophosphates: Search Terms 1 "Tris(2,3-dibromopropyl) phosphate" OR "TDBPP" OR "126-72-7" NA 2 "19186-97-1" NA 3 "Tris(2-chloroethyl)
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From page 73...
... bisphosphate" OR "Diethylene glycol tetra(2-chloroethyl) phosphate" OR NA "53461-82-8" 20 "UASQAKNFTHVEDR-UHFFFAOYSA-N" OR "3,9-Bis(3-bromo-2,2-bis(bromomethyl)
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From page 74...
... 74 A Class Approach to Hazard Assessment of Organohalogen Flame Retardants TABLE C-2 Continued Polyhalogenated organophosphates: Search Terms 47 #8 AND #23 3 48 #8 AND #24 2 49 #8 AND #25 1 50 #9 AND #23 311 51 #9 AND #24 63 52 #9 AND #25 218 53 #10 AND #23 1 54 #10 AND #24 0 55 #10 AND #25 1 56 #11 AND #23 0 57 #11 AND #24 0 58 #11 AND #25 0 59 #12 AND #23 0 60 #12 AND #24 0 61 #12 AND #25 0 62 #13 AND #23 0 63 #13 AND #24 0 64 #13 AND #25 0 65 #14 AND #23 14 66 #14 AND #24 9 67 #14 AND #25 3 68 #15 AND #23 0 69 #15 AND #24 0 70 #15 AND #25 0 71 #16 AND #23 185 72 #16 AND #24 19 73 #16 AND #25 95 74 #17 AND #23 4 75 #17 AND #24 3 76 #17 AND #25 4 77 #18 AND #23 2 78 #18 AND #24 0 79 #18 AND #25 2 80 #19 AND #23 0 81 #19 AND #24 0 82 #19 AND #25 0 83 #20 AND #23 0 84 #20 AND #24 0 85 #20 AND #25 0 86 #21 AND #23 0 87 #21 AND #24 0 88 #21 AND #25 0 89 #22 AND #23 0 90 #22 AND #24 0 91 #22 AND #25 0 * The PubMed results have not been deduplicated.
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Key Terms

  • increase activity
  • receptor transcriptional
  • decrease activity
  • sex hormone
  • alpha transcriptional

  • receptor alpha
  • polyhalogenated bisphenol
  • organohalogen flame
  • search terms
  • flame retardants

  • estrogen receptor
  • human estrogen
  • bisphenol aliphatics
  • androgen receptor
  • activated receptor

  • proliferator activated
  • data availability
  • diphenyl ethers
  • mitochondrial membrane
  • gamma transcriptional

  • x receptor
  • receptor gamma
  • human androgen
  • increase production
  • human peroxisome

  • aliphatic carboxylate
  • peroxisome proliferator
  • aliphatic chains
  • phenol deriv
  • benzene aliphatics


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