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Appendix D: Summary of Zebrafish Studies
Pages 75-90

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From page 75... ... Two (TBBPA) on thyroid homeostasis in zebrafish; Table D-4, OFR subclasses, the polyhalogenated organophosphates data from studies of the effects of polyhalogenated biand the polyhalogenated bisphenol aliphatics, were se- sphenols on zebrafish development or behavior; and Table lected as the case examples. Read the entire page →
From page 76... ... microarray and qRT-PCR hpf in 1- and 3-µM for transcript expression treatment groups; 17 genes and protein expression, with altered expression at proteomics. 4 hpf in 3-µM treatment group; qRT-PCR and Western blot analysis confirmed transcript- and protein-expression changes in 8 target genes; proteomics on 96 hpf larvae in 0.2,- 1-, and 3-µM treatment groups showed 15 proteins with altered expression. Read the entire page →
From page 77... ... 10 µM; teratogenic; (2014) neurobehavioral effect threshold of 3.14 µm. Read the entire page →
From page 78... ... developmental toxicity in larvae; 42 for 5-µg/L treatments in transcript levels in F1 males; 2.8 ng/g at 0.5 µg/L and 11 ng/g at 5 µg/L in F1 eggs; significant decrease in body mass and length in females in 5 µg/L treatment; females, down regulation of gh in both treatments in brain and down regulation of ghra, ghrb, igf1, and igf1ra in both treatments and of igf1rb at higher treatment in liver; decrease in survival in 3 and 5-dpf F1 larvae in higher treatment group; decreased heart rate in 3-dpf larvae in both treatment groups; decreased body length in 5-dpf larvae in both treatment groups; in 5 dpf larvae: down-regulation of gh and igf1 in offspring of higher treatment group. (Continued) Read the entire page →
From page 79... ... Appendix D 79 TABLE D-1 Continued Life Stage at Life Stage Chemical Exposure Analyzed Concentrations Outcomes Assessed Results Reference TDCPP 2 hpf through Adults (age not 4, 20, 100 µg/L Developmental toxicity Increase in malformations in F1 Wang et al. sexual maturation specified) Read the entire page →
From page 80... ... ; 5-dpf larvae had decreased dopamine and GABA in 20- and 100-µg/L groups and decreased serotonin in 100-µg/L group; 10-dpf larvae had decreased dopamine and histamine in 20- and 100-µg/L groups and decreased GABA and serotonin in 100-µg/L group; no change in AChE activity in larvae; swimming speed reduced in 100-µg/L group at 5 and 10 dpf; ROS was increased in 100-µg/L group at 5 and 10 dpf. TCEP 5.25–96 hpf Larval (96 hpf) Read the entire page →
From page 81... ... neurobehavioral effect threshold 0.56 µM. Abbreviations: ACh, acetylcholine; AChE, acetylcholinesterase; AhR, aryl hydrocarbon receptor; dpf, days post-fertilization; BChE, butyrylcholine esterase; EC50, effect concentration at which 50% of the population is affected; ER, estrogen receptor; GABA, γ-aminobutyric acid; GR, glycocorticoid receptor; hpf, hours post-fertilization; LC50, lethal concentration at which 50% of the population is killed; mpf, months post-fertilization; MR, mineralocorticoid receptor; NA, not available; NOAEL, no-observedadverse-effect level; NOEL, no-observed-effect level; PPARα, peroxisome proliferator-activated receptor alpha; qRT-PCR, quantitative real-time polymerase chain reaction; TCEP, tris(2-chloroethyl) Read the entire page →
From page 82... ... increased after low treatment and decreased µg/L (1/100 after high treatment; in males, ROS increased 96-h LC50 -- and GSH decreased after both treatments and low) Mn-SOD and Cu/Zn-SOD decreased after high treatment; transcript expression of genes related to the defense system increased in both sexes after low treatment and decreased in both sex after high treatment; decrease in transcript expression in females (except an increase in cyclin 1A) Read the entire page →
From page 83... ... mg/L gene transcription. mg/L; 11-KT decreased in males at 0.04, 0.2, and 1 mg/L; cyp17 and cyp19a expression increased at 1 mg/L in males and females; vtg increased at 1 mg/L in males and decreased at 0.2 and 1 mg/L in females. Read the entire page →
From page 84... ... 100, 200, 300, 400 µg/L Transcript expression, Up-regulation of trα (100, 200 µg/L) Baumann et al. Read the entire page →
From page 85... ... hpf) activity developmental exposure resulted in no behavioral change. Read the entire page →
From page 86... ... Abbreviations: dpf, days post-fertilization; dph, days posthatching; EC50, effect concentration at which 50% of the population is affected; hpf, hours post-fertilization; LC50, lethal concentration at which 50% of the population is killed; mpf, months postfertilization; TBBPA, tetrabromobisphenol A; TBBPA-BHEE, tetrabromobisphenol A bis(2-hydroxyethyl) ether; TBBPABDBPE, 3,3′,5,5′-tetrabromobisphenol A bis(2,3-dibromopropyl) Read the entire page →
From page 87... ... (2011) receptors and/or peroxisome proliferator activated receptors Abbreviations: dpf, days post-fertilization; dph, days posthatching; hpf, hours post-fertilization; Hsp, heat-shock protein; LC50, lethal concentration at which 50% of the population is killed; LPO, lipid peroxidation; mpf, months post-fertilization; NA, not available; TBBPA, tetrabromobisphenol A; TCBPA, tetrachlorobisphenol A; vtg, vitellogenin. Read the entire page →
From page 88... ... 2015. Aryl using a battery of assays for developmental toxicity, organophosphate flame retardants induced cardiotoxicity neurotoxicity, cardiotoxicity and hepatotoxicity toward during zebrafish embryogenesis: by disturbing expression human relevance. Read the entire page →
From page 89... ... 2018. Developmental of the organophorous flame retardant 1,3-dichloro-2 exposure to an organophosphate flame retardant alters propyl phosphate causes thyroid endocrine disruption later behavioral responses to dopamine antagonism in and developmental neurotoxicity in zebrafish larvae. Read the entire page →
From page 90... ... Yu, Z TBBPA induces developmental toxicity, oxidative stress, Han, and C Read the entire page →

From page 75...

... Two (TBBPA) on thyroid homeostasis in zebrafish; Table D-4, OFR subclasses, the polyhalogenated organophosphates data from studies of the effects of polyhalogenated biand the polyhalogenated bisphenol aliphatics, were se- sphenols on zebrafish development or behavior; and Table lected as the case examples.

Appendix D: Summary of Zebrafish Studies Pages 75-90

Appendix D: Summary of Zebrafish Studies
Pages 75-90