The Use of Systematic Review in EPA's Toxic Substances Control Act Risk Evaluations (2021) / Chapter Skim
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1 Introduction
1 Introduction
Pages 9-13
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From page 9... ...
The risk evaluations consider both human health and ecological risks and must consider risks to susceptible and highly exposed populations; unreasonable risks identified in the risk evaluation must be eliminated; and the agency is provided expanded authority to more quickly require development of chemical information when needed. The new authority afforded to the agency also put tremendous time pressure on OPPT to assemble teams, promulgate rules, and draft the guidance documents and related operating procedures that prescribe how OPPT responds to its mandate.
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From page 10... ...
Furthermore, the preamble states that it will not limit the use of a systematic review approach solely to the hazard assessment but will use it throughout the risk evaluation process. As defined by the 2011 Institute of Medicine report Finding What Works in Health Care: Standards for Systematic Reviews, systematic review is "a scientific investigation that focuses on a specific question and uses explicit, prespecified scientific methods to identify, select, assess, and summarize the findings of similar but separate studies.
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From page 11... ...
. Methods have also been proposed for applying systematic review methods to risk evaluations for ecological receptors in a framework integrated with human health risk evaluations (Suter et al.
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and associated materials. The committee will consider public comments on the document, EPA's responses to public comments, and enhancements to the system atic review process reflected in documentation of the first 10 chemical risk evaluations.
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From page 13... ...
For each systematic review step, the committee provides a brief overview of the state of the practice, describes how the step is applied in TSCA risk evaluations, critiques the approach used in TSCA risk evaluations, and then provides recommendations for improvement for each step. Chapter 3 addresses crosscutting and more general issues related to the use of systematic review in TSCA risk evaluations.
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