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Achieving Excellence in Sepsis Diagnosis: Proceedings of a Workshop - in Brief
Pages 1-10

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From page 1...
... This workshop was the first in a series of three workshops on diagnostic excellence funded by the Gordon and Betty Moore Foundation.2 This Proceedings of a Workshop -- in Brief highlights presentations and discussions that occurred at the workshop.3 BACKGROUND Harvey Fineberg from the Gordon and Betty Moore Foundation described the concept of diagnostic excellence, noting that it requires more than preventing diagnostic errors. He stated that diagnostic excellence should span the entire patient experience of the diagnostic process and consider factors such as the appropriateness and efficiency of diagnostic testing as well as workforce, health care infrastructure, and financial costs.
From page 2...
... pandemic could inform future efforts to achieve diagnostic excellence. Fineberg agreed, noting that the pandemic has increased the urgency and public awareness of the importance of accurate and timely diagnosis, especially for an infectious disease with significant public health implications.
From page 3...
... Thus, although biomarkers of organ dysfunction hold promise for earlier intervention and improved patient outcomes, their application in clinical practice is premature. Timothy Sweeney from Inflammatix, Inc., described his experience developing novel diagnostic tools for sepsis.
From page 4...
... Sweeney stressed the importance of considering timing and workflow when developing novel diagnostic strategies, because even perfect diagnostic tools are not useful in clinical practice if they fail to deliver actionable results within an appropriate timeframe. Sweeney stressed that diagnostic test developers need to look beyond the quality of the test itself to ensure that it can be appropriately integrated within clinical workflow to improve patient outcomes.
From page 5...
... He suggested that improvements in EHR interoperability have set the stage for the implementation of technical standards to improve sepsis diagnosis and treatment, but there is still progress to be made in strengthening data governance and security, protecting patient privacy, and ensuring broader implementation and uptake. Uniting data elements and allowing information to flow seamlessly across applications can allow health care systems to improve patient care by learning "dynamically from every patient that comes in the door." Jeremy Kahn from the University of Pittsburgh discussed policy approaches to improving sepsis diagnosis.
From page 6...
... Kahn went on to propose two shorter-term policy solutions for improving diagnostic quality: adopting holistic policies that address the full clinical process from diagnosis through resolution, and rewarding team-based care, including performance incentives for nonphysician clinicians. As an example of a holistic policy applied to sepsis diagnosis, he described New York State's sepsis regulations, which include protocols for the recognition and treatment of sepsis, staff education, reporting of both process and outcome data, and communication with patients' families (New York State, 2015, 2018)
From page 7...
... He suggested looking beyond mortality outcomes to consider outcomes that more fully capture diagnostic excellence, including the overuse of diagnostic testing and treatment, missing diagnoses, and delays in diagnosis. Michael Howell from Google Health considered the role of early recognition and treatment of infection as a potential way of eliminating sepsis.
From page 8...
... 2019. A machine learning algorithm to predict severe sepsis and septic shock: Development, implementation, and impact on clinical practice.
From page 9...
... 2016. Developing a new definition and assessing new clinical criteria for septic shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
From page 10...
... , University of California, San Francisco; Derek Angus, University of Pittsburgh; Pascale Carayon, University of Wisconsin–Madison; Gari Clifford, Emory University; Laura Evans, University of Washington; Kathryn McDonald, Johns Hopkins University; Lyle Moldawer, University of Florida; and Saul Weingart, Tufts University. REVIEWERS: To ensure that it meets institutional standards for quality and objectivity, this Proceedings of a Workshop -- in Brief was reviewed by Vincent Liu, Kaiser Permanente, and Christine Goeschel, MedStar Health.


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