Roundtable on Genomics and Precision Health 2016 Annual Report (2017) / Chapter Skim
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Roundtable on Genomics and Precision Health: 2016 Annual Report
Roundtable on Genomics and Precision Health: 2016 Annual Report
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Roundtable on Genomics and Precision Health 2016 Annual Report
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In 2016, the Roundtable convened a public workshop that explored novel business models and partnerships that facilitate the use of genetic data in the drug discovery process. As part of an ongoing collaboration with the Forum on Drug Discovery, Development, and Translation, the Roundtable will host a follow-up public workshop in 2017 focused on exploring methods for utilizing genetic information to boost clinical trial enrollment rates, reduce inefficiencies in the current drug development paradigm, and enable precision medicine.
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Lastly, the Genomics and Population Health action collaborative began compiling information for an online resource guide, which will provide information and support to state public health officials who are interested in launching or expanding genomics programs at the population level. The Roundtable members will continue to identify key issues in the evidence evaluation process for genomic technologies, approaches to educating health care providers about genomics, integrating genomic information into electronic health records (EHRs)
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The Roundtable also convened a public workshop titled Deriving Drug Discovery Value from Large-Scale Genetic Bioresources.
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The Roundtable on Genomics and Precision Health and the Forum on Drug Discovery, Development, and Translation hosted a workshop that assessed the current landscape of genomic-enabled drug discovery and development activities in industry, academia, and government, examined enabling partnerships and business models, and considered gaps and best practices in how data from populations could be collected with the goal of improving the drug discovery process.
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Mobile Health and Genomics This group is exploring the landscape at the intersection between mHealth technologies and genomic data by examining how the two fields can interface to enable precision health, advance research (e.g., patient reported outcomes, continuous phenotypes) , and improve clinical care (e.g., monitoring, feedback, adherence)
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Currently, this group is focusing its efforts on precision medicine and precision health.
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In addition, the Roundtable will continue to discuss policy and implementation challenges surrounding global applications of genomic medicine, integrating genetics and genomics into the EHR, and enabling a new drug development paradigm through genomics. Action Collaboratives The Action Collaborative on Displaying and Integrating Genetic Information Through the EHR (DIGITizE)
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A Genomics and Population Health Action Collaborative was initiated at the end of 2015 to explore opportunities for genomics to be used to improve health and prevent disease and death; inform and engage various stakeholders about the implementation of genomics in practice; and assess how evidence-based genomic applications could be integrated into implementation activities and programs at the health care–public health interface. As an activity of the Roundtable, the Action Collaborative on Genomics and Population Health is seeking to develop methods for assessing best practices and outcomes for implementation of genomic applications and their impact in practice; develop a framework for tools and education materials to increase uptake of genomic applications in health care and disease prevention (such as a plan for a public health genomics toolkit)
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David Lanfear, M.D. American College of Medical Genetics Blue Cross and Blue Shield Association American Heart Association and Genomics Nazneen Aziz, Ph.D.
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National Society of Genetic Counselors Eli Lilly and Company Northrop Grumman Food and Drug Administration PhRMA Patient Advocacy Foundations 4% Government and Associations 34% 31% 31% Industry
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Timeline 2007 | July 11-12 Meeting 1 | December 4 Diffusion and Facilitating Development and Utilization of Genome Use of Genomic Innovations in Health and Medicine Based Diagnostic Technologies Workshop | Workshop | December 5 Meeting 2 November 16 Meeting 15 2008 | April 1-2 Meeting 3 | July 28 Innovations in Service 2012 | March 21 New Paradigms in Drug Discovery: How Delivery in the Age of Genomics Workshop | July 29 Genomic Data Are Being Used to Revolutionize the Meeting 4 | October 6-7 Meeting 5 Drug Discovery and Development Process Workshop | March 22 Meeting 16 | May 24 Evidence for Clinical Utility of Molecular Diagnostics in Oncology Workshop 2009 | February 12 Systems for Research and Evaluation | July 17-18 Assessing the Economics of Genomic for Translating Genome-Based Discoveries for Health Medicine Workshop | July 18 Meeting 17 | October 4-5 Workshop | February 13 Meeting 6 | June 9-11 Sharing Clinical Research Data Workshop | December 3 Meeting 7 | August 31-September 1 Direct-to-Consumer Improving the Efficiency and Effectiveness of Genomic Genetic Testing Workshop | November 16-17 Meeting 8 Science Translation Workshop | December 4 Meeting 18 2010 | March 22 The Value of Genetic and Genomic 2013 | February 27 Refining Processes for the Technologies Workshop | March 23 Meeting 9 Co-Development of Genome-Based Therapeutics and | May 24 Challenges and Opportunities in Using Companion Diagnostic Tests Workshop | February 28 Newborn Screening Samples for Translational Meeting 19 | June 5 Conflict of Interest and Medical Research Workshop; Meeting 10 | July 22 Establishing Innovation: Ensuring Integrity While Facilitating Precompetitive Collaborations to Stimulate Genomics Innovation in Medical Research Workshop | Driven Drug Development Workshop | July 23 June 24 Genomics-Enabled Drug Repositioning and Meeting 11 | November 17 Generating Evidence for Drug Repurposing Workshop | June 25 Meeting 20 | Genomic Diagnostic Test Development Workshop | December 4-5 Meeting 21 November 18 Meeting 12 2014 | February 3 Assessing Genomic Sequencing 2011 | February 22-23 Meeting 13 | July 19 Integrating Information for Health Care Decision Making Workshop Large-Scale Genomic Information into Clinical Practice | February 4 Meeting 22 | August 18 Improving Workshop | July 20 Meeting 14 | November 15 Genetics Education in Graduate and Continuing Health
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Reports Released in 2016 Professional Education Workshop | August 19 Meeting 23 | December 8 Genomics-Enabled Learning Applying an Implementation Health Care Systems: Gathering and Using Genomic Science Approach to Genomic Information to Improve Patient Care and Research Medicine: Workshop Summary Workshop | December 9 Meeting 24 2015 | March 10-11 Meeting 25 | July 14-15 Meeting 26 | November 19 Applying an Implementation Science Approach to Genomic Medicine Workshop | November 20 Meeting 27 2016 | March 22 Deriving Drug Discovery Value from Large Scale Genetic Bioresources Workshop | March 23 Meeting 28 | July 19-20 Meeting 29 | November 9 Meeting 30 2017 | March 8 Enabling Precision Medicine: The Role Deriving Drug Discovery Value of Genetics in Clinical Drug Development Workshop from Large-Scale Genetic | March 9 Meeting 31 | July 17-18 Meeting 32 | Bioresources: Proceedings of a November 1 | Exploring the Integration of Genomics Workshop into Population-Level Health Programs | November 2 Meeting 33
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More than 20 individuals who downloaded the workshop summary indicated that they will use the publication to inform their efforts in implementing genomics programs. 2016 Roundtable publications have been downloaded in more than 110 countries, for a total of more than 4,600 times.
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Genomics and Population Health Action Collaborative Participants in this collaboration developed components for an online toolkit related to horizon scanning and implementation outcome measures. The online toolkit will be used as a resource for public health programs interested in integrating genomics.
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The Roundtable will discuss the translation process, identify challenges at various points in the process, and discuss approaches to address those challenges. For more information about the Roundtable on Genomics and Precision Health, please visit our website at nas.edu/genomicsRT or call Sarah Beachy at (202)
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