Thriving in Space Ensuring the Future of Biological and Physical Sciences Research: A Decadal Survey for 2023-2032 (2023) / Chapter Skim
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Appendix D: Complementarity of NASA's Division of Biological and Physical Sciences and Human Research Program
Appendix D: Complementarity of NASA's Division of Biological and Physical Sciences and Human Research Program
Pages 288-298
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From page 288... ...
To emphasize, NASA's BPS Division rests within the Science Mission Directorate and sponsors scientific research to answer fundamental questions requiring access to space, among other important roles in science-focused missions. Separately, the HRP is a NASA program within the Human Exploration and Operations Mission Directorate, focused on discovering the best methods and technologies to support safe, productive human space travel.
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From page 289... ...
With this context specific to NASA organization, the research areas below are those that were discussed within the BPS decadal survey, with thoughtful input across the BPS research community. These research areas are not an exhaustive list of complementary research areas between HRP and the BPS Division, but they are those developed in the process of considering potential scientific questions of interest to the BPS community.
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From page 290... ...
To address the premise that exposure to the spaceflight environment represents an environment of accelerated aging study, 3D cell models have recently been explored on the International Space Station (ISS) as part of an NIH initiative.1 This initiative comprised nine separate projects that explored the effects of spaceflight on a spectrum of 1 National Institutes of Health, "Tissue Chip for Drug Screening," updated May 10, 2023, https://ncats.nih.gov/tissuechip.
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From page 291... ...
To effectively answer these questions, future studies focused on improving long-term monitoring of aging markers in current and former space travelers are required. Is it possible to alter and/or leverage the regenerative capacity of stem cells to develop targeted countermeasures for the physiological stress induced by space exploration?
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From page 292... ...
For example, new functional dentate granule cells deriving from adult neural stem cells are formed during adult hippocampal neurogenesis and then integrated into the existing neural circuits. These cells are particularly vulnerable to galactic cosmic radiation.
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From page 293... ...
. Studies in both animal models and humans have shown that the spaceflight environment can influence mitogen-induced proliferation, cytokine production and reactivity (Baqai et al.
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From page 294... ...
. Future work is required to establish whether reversing headward fluid shifts for brief periods each day (e.g., by lower body negative pressure [LBNP]
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1996. "Myonuclear Number and Myosin Heavy Chain Expression in Rat Soleus Single Muscle Fibers After Spaceflight." Journal of Applied Physiology 81(1)
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2000. "Physiology of a Microgravity Environment Invited Review: Microgravity and Skeletal Muscle." Journal of Applied Physiology 89(2)
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2020. "Feasibility, Potency, and Safety of Growing Human Mesenchymal Stem Cells in Space for Clinical Application." npj Microgravity 6:16.
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2009. "Exercise in Space: Human Skeletal Muscle After 6 Months Aboard the International Space Station." Journal of Applied Physiology (1985)
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