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Review of EPA's 2022 Draft Formaldehyde Assessment (2023) / Chapter Skim
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Appendix E: Examples of Issues Identified by the Committee
Pages 148-155

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From page 148...
... : literature identification, study evaluation criteria, synthesis and judgments including any mode of action considerations, overall hazard conclusions, and dose-response evaluation. A final section details some general issues identified by the committee.
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From page 149...
... If it is not a true random sample, there could be additional potential for selection bias. For pulmonary function, while the study evaluation criteria provided in Table A-43 appear to be appropriate, they do not overlap with the methodologic issues mentioned in the text.
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From page 150...
... The classification scheme in Figure II would sug gest this study is of medium confidence, but a fully colored box likely means something more, which needs to be explained. EVIDENCE SYNTHESIS AND JUDGMENTS Regarding pulmonary function, Table 1-11 indicates there are multiple additional studies included in the evidence judgment for long-term effects, although none of these are referenced.
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From page 151...
... EPA needs to document whether the evidence integration summary tables in the Main Assessment and Assessment Overview are identical. DOSE-RESPONSE EVALUATION Regarding sensory irritation, in Tables 1-1 and 1-2, several studies have been identified as high or medium confidence, but only six were included in the sensory irritation dose-response analysis (Table 2-1)
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From page 152...
... . EPA did not disclose whether it obtained raw data or extracted secondary data from the original report.
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From page 153...
... 2021. "Joint and interactive effects between health comorbidities and environmental exposures in predicting amyotrophic lateral sclerosis." Int J Hyg Environ Health 231: 113655.
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From page 154...
... 2008. "Ambient formal dehyde levels and allergic disorders among Japanese pregnant women: baseline data from the Osaka maternal and child health study." Ann Epidemiol 18 (1)
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From page 155...
... 2017. "Occu pational formaldehyde and amyotrophic lateral sclerosis." Eur J Epidemiol 32 (10)
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Key Terms

  • sensory irritation
  • animal studies
  • lateral sclerosis
  • medium confidence
  • human studies

  • low confidence
  • study evaluation
  • random sample
  • amyotrophic lateral
  • raw data

  • evaluation criteria
  • formaldehyde exposure
  • regression model
  • controlled trials
  • selection bias

  • reproductive toxicity
  • mobile homes
  • indoor formaldehyde
  • main assessment
  • secondary data

  • formaldehyde vapor
  • male reproductive
  • child health
  • epa extracted
  • draft assessment

  • assessment overview
  • formaldehyde concentrations
  • registry data
  • animal data
  • environ health


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