Biographical Memoirs Volume 65 (1994) / Chapter Skim
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7. Louis Frederick Fieser
7. Louis Frederick Fieser
Pages 160-175
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From page 161... ...
He retained a robust athletic ability well into micictle age; many of his graduate students will recall his feat of swimming the entire length of the Harvard pool under water, a feat none of them couIcI cluplicate. Graduate study at Harvard uncler James Bryant Conant followed his years at Williams, leading to the Ph.D.
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From page 162... ...
, the fames Flack Norris Award in the Teaching of Chemistry (1959) , the Manufacturing Chemists Association Award in Teaching (1959)
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From page 163... ...
While at Bryn Mawr Fieser met Mary Peters, a member of his second class, who, after graduating from Bryn Mawr, entered Radcliffe College to undertake graduate study under Fieser's direction. They were marries!
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From page 164... ...
This period saw the development of synthetic methods for the polycyclic aromatic hydrocarbons, efficient syntheses for such important carcinogenic substances as 20-methylcholanthrene, 3,4-benzpyrene, and their alkyl derivatives and the general exploration of the relationship between structure and carcinogenic activity among the polycyclic aromatic hydrocarbons. Studies on resin acids and the application of ultraviolet absorption spectroscopy to problems in organic chemistry were also carried out, the latter at a time before recording spectrophotometers made this an easy task.
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From page 165... ...
A brief excursion into the area of mixecl aliphatic-aromatic polynitro compounds for possible use as exotic explosives was followed by studies of alkali salts of Tong chain fatty acids as incendiaries, but by far the most important of his war-related work was his Tong and intensive study of the quinone antimalarials. This important work was published in a series of some thirty papers, mostly (luring 1948-50, and in several review articles.
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From page 166... ...
Pharmaccutical firms throughout the world undertook programs in this highly competitive area. Fieser's Natural Products Reilated to Phenanthrene in its various editions proved to be invaluable as a source book and reference, particularly its fourth edition, renamed Steroids with a corresponding change in emphasis.
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From page 167... ...
only by lengthy and cumbersome procedures; his method comprised conversion to the hydroquinone whose unusual solubility properties allowed an easy purification. Reconversion to the quinone gave the pure vitamin, with which his synthetic sample was identical in all respects.
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From page 168... ...
His success at instilling interest and inspiring enthusiasm in these undergraduates is well-illustratec! by the example of one member of his class who, after entering Harvard Meclical School, came back to Fieser's laboratory every summer of meclical school to continue work he had begun as an un(lergra(luate; by the time he began interning they had jointly publishe(1 seventeen papers.
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From page 169... ...
The principal competing series suffers grievously from a cumbersome and ctifficult organization. Expert men ts in Organic Chemistry in its various editions contained several very useful chapters on reagents and reactions, techniques, apparatus, and other sugestions for advanced work.
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From page 170... ...
That his wife and collaborator was in no small way influential in this process is evident from the fact that the book referred to above grew out of a set of notes on grammar, rhetoric, and style prepared by Mary Fieser for incorporation into a pamphlet for contributors to Organic Reactions. The method by which the Fiesers collaborated on their books has been described by Fieser himself: "Mary prepared large stacks of uncorrelated surveys in various stages of completion," which were then reworked, organized, and integrated by him.
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From page 171... ...
As Mary Fieser has put it, he approached chemistry "as a kind of sport, not just harcl work. ~ think he really enjoyed!
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From page 172... ...
58:2482. Natural Products Related to Phenanthrene.
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From page 173... ...
Introduction to Organic Chemists. With Mary Fieser.
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From page 174... ...
1961 With Mary Fieser. Advanced Organic Chemistry.
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From page 175... ...
LOUIS FREDERICK FIESER 175 ^8 aft fit, ~ ^~7 If ~ ^~/ ^~3 {~ ^r ^~ Beg Irk: Reinhold. ^~ i~ ^~ ~~ ~Hwaukee: Aldrich.
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