Biographical Memoirs Volume 65 (1994) / Chapter Skim
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8. Karl Paul Link
8. Karl Paul Link
Pages 176-195
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From page 177... ...
work on the isolation and characterization of the hemorrhagic factor produced in spoiled sweet clover hay. The isolation of a modified coumarin as the causative agent led Link and his colleagues to the synthesis of a variety of anticoagulants that have hacI wide medical application as anticlotting agents and that have also proved highly effective as roclenticides.
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From page 178... ...
Karl's sister Margret states that, "There always was enough food for the family, we were adequately clothed wearing 'hancl me clowns,' given the best toys and of course many books. We often asked each other, how clicl our mother raise us when there was so little money?
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From page 179... ...
) was a registered nurse; Karl Paul ~ 1 90 1-78 )
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From page 180... ...
Large bow ties, flannel shirts, work shoes, shorts, and sometimes the cape combined with his flowing locks gave him a distinctive ap.
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From page 181... ...
protocatechuic acid and that it conferred resistance to the fungus Colletotr~chium circinans, the causative agents of onion smudge. In contrast, the white onions lacked protocatechuic acid and were susceptible.
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From page 182... ...
That fall ~ enrolled in the general course in agricultural chemistry. It was a staff course taught by Link, W
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From page 183... ...
However, his fame rests chiefly on his work with blood anticoagulants. The story has been told many times of the farmer coming to Link's lab with blood from a cow that had died from hemorrhaging after eating spoilecl sweet clover hay.
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From page 184... ...
After farmer Carlson left, Schoeffel stormed back and forth in the laboratory shouting, '\at da Hell, a farmer shtruggles nearly 200 miles in dis Sau-wetter, driven by a shpectre and den has to go home vit promises dat might come true in five, ten, fifteen years, maybe never. Who knows?
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From page 185... ...
Although he had almost completed his thesis work, at Link's request he now turned his attention to isolation of the anticoagulant following Campbell's research. He acquired a number of oak barrels and initiated large-scale extraction of spoiled sweet clover hay that hack been storecl by Roberts in the campus horse barn.
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From page 186... ...
Harold Campbell, Ralph Overman, Charles Huebner, and Mark Stahmann have led to the elucidation of the chemical structure of the hemorrhagic agent present in spoiled sweet clover hay, and to its synthesis from known starting products. The hemorrhagic agent (6.0 mg.)
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From page 187... ...
This compound was synthesized in 1903 by the German chemists Anschutz and Fresenius, but Campbell's isolation from toxic sweet clover hay represents to our knowledge the first time that this substance has been found in nature. Naturally the prothrombin-destroying properties of the substance escaped the pioneer organic chemists....
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From page 188... ...
In the fall of 1945 Link tract a recurrence of his TB. He spent a couple of months in Wisconsin General Hospital and then moved to the Lake View Sanatorium for six months.
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From page 189... ...
He was censured by the University of Wisconsin Board of Regents in 1952 when he charged publicly that the university administrators failecI to cooperate with him in supporting his research on calf scours, forcing him to take the project out of state. He was fortunate to have a stalwart ally in E
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From page 190... ...
At a biochemistry staff meeting he offered his opinion on an issue at some length. A new staff member, who had switched from physics to biochemistry and was unacquainted with Karl's carefully cultivated role as champion of liberal causes, stated after Karl's comments, "Spoken like a true conservative." Karl was crushed.
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From page 191... ...
Link clid serve as faculty sponsor for certain left-wing groups (the John Cookson Karl Marx Discussion Group, the labor Youth League, and The Folk Arts) , and this was accompanied by extensive press coverage and increased visibility.
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From page 192... ...
There were tributes by his family, his students, faculty members, and other friends. A Karl Paul Link Fellowship was establisher!
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From page 193... ...
IN PREPARING THIS memoir, I have consulted the extensive files on Karl Paul Link maintained by the Department of Biochemistry, University of Wisconsin. I also thank P
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From page 194... ...
The isolation of protocatechuic acid from pigmented onion scales and its significance in relation to disease resistance in onions.
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From page 195... ...
KARL PAUL LINK 1952 195 With C
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