Environmental Medicine Integrating a Missing Element into Medical Education (1995) / Chapter Skim
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Case Study 21: Mercury in House Paint as a Cause of Acrodynia: Effect of Therapy with N-Acetyl-D, L-Penixillamine
Case Study 21: Mercury in House Paint as a Cause of Acrodynia: Effect of Therapy with N-Acetyl-D, L-Penixillamine
Pages 445-449
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From page 445... ...
when given for therapy of acrodynia did not significantly increase mercury excretion.'6 Increased urinary elimination of mercury during penicillin therapy for infection has been observed,l7 but the results of penicillin therapy in acrodynia have been equivocal.l7'l~ Aposhianl9 20 has shown that N-acetyl-D,~-penicillamine is more effective than other penicillamine derivatives in protecting laboratory animals from induced inorganic mercury poisoning and that its toxicity is considerably less.l920 Smith and Millers reported the successful treatment of mercury poisoning in a gilder with N-acetyl-D,~-penicillamine.
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From page 446... ...
Samples of urine were cold digested with potassium permanganate and sulfuric acid to destroy the organic material. The excess potassium permanganate was bleached with hydroxylamine hydrochloride, and after adjustment to a pH of 6, the solution of the soluble divalent mercury was passed through a glass filter impregnated with cadmium sulfide.
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From page 447... ...
The test panel continued to emit mercury vapor in diminishing amounts for 6 weeks despite continuous air exchanges. On the basis of an average volatilization rate of 0.50 microgm.
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From page 448... ...
Bower36 noted relief of all symptoms except for photophobia with sympatholytic drugs such as hexamethonium tartrate and pentolinium bromide; he confirmed the relief of arteriolar spasm in patients with acrodynia by these drugs. Ritzel, Berger and Roulet37 recently observed 'increased catechol amine excretion in a case of acrodynia.
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From page 449... ...
A Increased catecholamine excretion in case of acrodynia: (pink disease)
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