Biographical Memoirs Volume 69 (1996) / Chapter Skim
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ALBERT HEWITT COONS
ALBERT HEWITT COONS
Pages 26-37
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a major revolution in immunology en c! cell biology that continues to this clay by cleveloping the immunofluorescent technique for labeling specific antibodies with fluorescent dyes, thus permitting the detection of antibodies, antigens, and virtually any antigenic protein in cells en c!
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his clinical training, Dr. Coons began a research fellowship in the Department of Bacteriology en c!
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One afternoon I was thinking about rheumatic fever and about the Aschoff nodule, the microscopic lesion characteristic of it. It was at that time and I think probably in many circles still is, thought to be the result of a local hypersensitivity reaction involving components of the group A hemolytic strepto
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both support and encouragement from Dr. George Minot, director of the Thorndike Memorial Laboratory, and from John Enclers of the Department of Bacteriology en c!
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in demonstrating the feasibility of putting fluorescent tags on antibodies en c! using them to localize foreign antigens in host tissues.
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The fluorescent antibody technique permitter! the stucly of the fate of antigens in tissues, the expression of many different cell proteins in tissues, the identification of cells producing specific antibodies, detection of immune complexes en c!
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analysis of in vitro secondary antibody responses. These studies were among the first to establish reproclucible secondary antibocly responses in vitro, to demonstrate the critical role of early cellular proliferation in the in vitro secondary response, en c!
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en c! elegant iclea of putting a sensitive visible label on antibody molecules.
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II. The primary and secondary responses in the popliteal lymph node of the rabbit.
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Specific inhibition of antibody formation during immunologic paralysis and unresponsiveness. Nature 184:1080.
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